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Invitrogen™ SOCS1 Polyclonal Antibody

Código de producto. 11508021
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Cantidad:
200 μL
Tamaño de la unidad:
200 microlitros
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11508021 200 μL 200 microlitros
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Código de producto. 11508021 Proveedor Invitrogen™ N.º de proveedor PA141009

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Descripción

Rabbit Polyclonal Antibody

Suggested positive control: Ramos or RAW. This should cross-react with rat SOCS1, based on amino acid sequence. Immunogen sequence: HFRTFRSHAD YRRIT.

The Suppressor of cytokine signaling (SOCS) and cytokine-inducible SH2 proteins are a family of intracellular proteins which regulate the immune cell responses to cytokines. SOCS1 acts to suppress dendritic cell (DC) as well as T cell hyperactivation following cytokine signaling by inhibiting JAK tyrosine kinase, a kinase necessary for type I and II cytokine receptors to initiate signaling, by directly binding to the catalytic domain of the kinase. SOCS1 also possesses E3 ubiquitin protein ligase activity that results in the polyubiquitination of its target proteins and subsequent degradation by the proteosome. It is through this method that SOCS1 negatively regulates signaling by Toll-like receptors TLR2 and TLR4 by mediating the degradation of the TLR signaling adaptor protein TIRAP.
TRUSTED_SUSTAINABILITY

Especificaciones

Antígeno SOCS1
Aplicaciones Western Blot
Clasificación Polyclonal
Concentración 0.5 mg/mL
Conjugado Unconjugated
Formulación PBS with 0.05% BSA and 0.05% sodium azide
génica Socs1
N.º de referencia del gen O15524, O35716
Alias de gen CIS1; Cish1; Cish7; cytokine inducible SH2-containing protein 1; cytokine inducible SH2-containing protein 7; cytokine-inducible SH2 protein 1; JAB; JAK binding protein; JAK2-binding protein; JAK-binding protein; Socs1; SOCS-1; SSI1; SSI-1; STAT induced SH3 protein 1; STAT-induced STAT inhibitor 1; Suppressor of cytokine signaling 1; Tec-interacting protein 3; TIP3; TIP-3
Símbolos de los genes Socs1
Especie del huésped Rabbit
Inmunógeno A synthetic peptide corresponding to amino acids 54-68 of human SOCS1.
Cantidad 200 μL
Estado normativo RUO
Primario o secundario Primary
ID de gen (Entrez) 12703, 8651
Especies diana Human, Mouse
Contenido y almacenamiento Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Tipo de producto Antibody
Formulario Liquid
Isotype IgG
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