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  6. Thermo Scientific Chemicals SB 225002

Thermo Scientific Chemicals SB 225002

Código de producto. 15496869
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Código de producto. 15496869 Proveedor Thermo Scientific Chemicals N.º de proveedor J65387.MA
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Descripción

Un potente, selectivo y competitivo antagonista del receptor acoplado de proteína G CXCR2

SB 225002 is a selective non-peptide CXCR2 inhibitor which suppresses IL-8 induced neutrophil chemotaxis and margination. In addition, SB 225002 reduces MPO activity, IL-1β, MIP-2, and keratinocyte-derived chemokine (KC) levels. Further studies suggest that SB 225002 decreases the expression of vascular endothelial growth factor, inducible NOS (NO synthase), and Cox-2 (cyclooxygenase-2 proteins) in colon tissue.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

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Identificadores de productos químicos

CAS 182498-32-4
Fórmula molecular C13H10BrN3O4
Sinónimo 1-(2-bromofenil)-3-(2-hidroxi-4-nitrofenol)urea

Especificaciones

Cantidad 10mg
Descripción Amarillo
Contenido y almacenamiento De - 30 °C a - 10 °C
Para utilizar con (aplicación) Un potente, selectivo y competitivo antagonista del receptor acoplado de proteína G CXCR2
Formula Weight (peso de la fórmula) 352,10g/mol
Sensibilidad Sensible a la humedad
Solubilidad Soluble a 100 mm en DMSO y a 50 mm en etanol
Tipo de producto Reactivo de transducción de la señal
Formulario Sólido
Clave InChI MQBZVUNNWUIPMK-UHFFFAOYSA-N
SMILES OC1=C(NC(=O)NC2=CC=CC=C2Br)C=CC(=C1)[N+]([O-])=O
Nombre IUPAC 3-(2-bromophenyl)-1-(2-hydroxy-4-nitrophenyl)urea
Peso molecular (g/mol) 352.14
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