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  6. STEMCELL Technologies Rapamycin

STEMCELL Technologies Rapamycin

Código de producto. 15682517
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Cantidad:
1 mg
10 mg
Förpackningsstorlek:
1 miligramo
10 miligramos
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Produktkod. Cantidad unitSize
15682517 1 mg 1 miligramo
17130212 10 mg 10 miligramos
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Produktkod. 15682517 Leverantör STEMCELL Technologies Leverantörsnummer 73362

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Beskrivning

Antibiotic; mTOR pathway inhibitor; Inhibits FKBP-12

  • Rapamycin is a macrolide antibiotic and immunosuppressive compound that inhibits mammalian target of rapamycin (mTOR) signaling
  • It acts through formation of a complex with cytosolic FK-binding protein 12 (FKBP-12), which directly binds to mTOR complex 1 (mTORC1)
  • Its immunosuppressive effects are mediated through inhibition of IL-2 signaling that is critical for T-cell proliferation and activation (Gibbons et al.; Kay et al.) Rapamycin shows antifungal activity against Candida albicans and other fungi (Vézina et al.)
  • Inhibits growth of MDA-MB-468 human breast cancer cells in vitro, and inhibits tumor growth in a mouse xenograft model in vivo (Akcakanat et al.)
  • Induces autophagy in malignant glioma cells (Takeuchi et al.)

Specifikationer

CAS 53123-88-9
Cantidad 1 mg
Porcentaje de pureza ≥95%
Produkttitel
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