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Invitrogen™ PrP Monoclonal Antibody (EM-20)
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Código de producto. 12382173
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Cantidad:
100 μg
Tamaño de la unidad:
paquete de 100
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12382173 100 μg paquete de 100
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Código de producto. 12382173 Proveedor Invitrogen™ N.º de proveedor MA110152

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Mouse Monoclonal Antibody

This antibody recognizes human prion protein (PrP). Diglycosylated form of PrP has ~ 40 kDa, monoglycosylated form ~ 30 kDa, and nonglycosylated form ~ 19-21 kDa. This antibody is suitable for discrimination between normal cellular prion protein (PrPc) and its conformationally changed form (PrPSc) prion protein. Western Blot: non-reducing conditions are essential.

Human prion protein (PrP), also known as PRNP, is a ubiquitously expressed GPI-anchored cell surface glycoprotein associating with lipid raft components and functioning as a signaling molecule. PrP plays a role in apoptosis in a cell context-dependent manner, is involved in proliferation of epithelial cells and in distribution of junction-associated proteins in human enterocytes. Conversion of this normal cellular prion protein (PrPc) into an abnormal conformer (PrPSc) is the crucial step associated with triggering the pathogenesis of the prion neurodegenerative disorders, such as the Creutzfeld-Jakob disease (CJD). Whereas PrPc is rich in alpha-helices, the PrPSc form has higher content of beta-sheets and is resistant to proteinase K.
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Especificaciones

Antígeno PrP
Aplicaciones Western Blot
Clasificación Monoclonal
Clon EM-20
Concentración 1 mg/mL
Conjugado Unconjugated
Formulación PBS with 15mM sodium azide; pH 7.4
génica PRNP
N.º de referencia del gen F7VJQ1, P04156
Alias de gen AA960666; AI325101; Alternative prion protein; alternative prion protein; major prion protein; AltPrP; ASCR; BSE; CD230; CD230 antigen; CJD; GSS; KURU; major prion protein; major prion protein; alternative prion protein; major scrapie-associated fibril protein 1; MGC26679; p27-30; PK resistant core; prion protein; prion protein (p27-30) (Creutzfeldt-Jakob disease, Gerstmann-Strausler-Scheinker syndrome, fatal familial insomnia); prion protein precursor; prion protein precursor PrP; prion protein PrP; prion protein variant a; prion protein variant b; prion protein, PrP; prion protein, structural; prion-related protein; PRIP; Prn; Prn-i; Prnp; Prn-p; PrP; PrP>C>; PrP27-30; PrP33-35C; PrPc; PrPSc; Sinc; SIP; TSE
Símbolos de los genes PRNP
Especie del huésped Mouse
Inmunógeno Recombinant human prion protein.
Método de purificación Protein A
Cantidad 100 μg
Estado normativo RUO
Primario o secundario Primary
ID de gen (Entrez) 5621
Especies diana Human
Contenido y almacenamiento 4°C, do not freeze
Tipo de producto Antibody
Formulario Liquid
Isotype IgG2a
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