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Invitrogen™ Phospho-Paxillin (Ser178) Polyclonal Antibody

Descripción
This antibody detects a 68kDa* protein corresponding to the molecular mass of phosphorylated paxillin on SDS-PAGE immunoblots of EGF treated A431 cells, but not in A431 control cells. Similar results were seen in calyculin A treated human A431 and aortic endothelial cells.
Paxillin is a focal adhesion protein and a substrate for several tyrosine kinases such as src, FAK, and p210BRC/ABL. The tyrosine phosphorylation of paxillin is affected by conditions that change cell-cell adhesion. Paxillin associates tightly with FAK and Crk through its SH2 domain. This interaction is independent of the extracellular matrix. Although paxillin was initially discovered in fibroblasts, its phosphorylation may also be important during neurite extension during differentiation.
Especificaciones
Especificaciones
| Antígeno | Phospho-Paxillin (Ser178) |
| Aplicaciones | Immunohistochemistry (Frozen), Western Blot |
| Clasificación | Polyclonal |
| Concentración | 0.5 mg/mL |
| Conjugado | Unconjugated |
| Formulación | PBS with 1mg/mL BSA, 50% glycerol and 0.05% sodium azide |
| génica | PXN |
| N.º de referencia del gen | P49023, Q66H76, Q8VI36 |
| Alias de gen | adaptor protein; AW108311; AW123232; FLJ16691; hCG_1778014; I79_001229; myocardial ischemic preconditioning associated protein 7; Pax; PAX-1; PAXI; Paxillin; paxillin a; paxillin alpha; pxn; pxna; testicular tissue protein Li 134; TGFB1I1; transforming growth factor beta 1 induced transcript 1; wu:fw71f12 |
| Símbolos de los genes | PXN |
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Título del producto
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