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Invitrogen™ Phospho-MSK1 (Thr581) Polyclonal Antibody
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Código de producto. 17752744
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Cantidad:
100 μL
Tamaño de la unidad:
100 microlitros
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17752744 100 μL 100 microlitros
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Código de producto. 17752744 Proveedor Invitrogen™ N.º de proveedor PA5121347

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Rabbit Polyclonal Antibody

The target is usually found in the following locations: Cytoplasm, Nucleus. Immunogen sequence: LKTPC.

RPS6KA5 (MSK1) is a serine/threonine protein kinase that is essential for the regulation of various cellular processes. RPS6KA5 is required for the mitogen or stress-induced phosphorylation of the transcription factors CREB1 and ATF1 and for the regulation of the transcription factors RELA, STAT3 and ETV1/ER81, and that contributes to gene activation by histone phosphorylation and functions in the regulation of inflammatory genes. Phosphorylates CREB1 and ATF1 in response to mitogenic or stress stimuli such as UV-C irradiation, epidermal growth factor (EGF) and anisomycin. Plays an essential role in the control of RELA transcriptional activity in response to TNF and upon glucocorticoid, associates in the cytoplasm with the glucocorticoid receptor NR3C1 and contributes to RELA inhibition and repression of inflammatory gene expression. In skeletal myoblasts is required for phosphorylation of RELA at 'Ser-276' during oxidative stress. In erythropoietin-stimulated cells, is necessary for the 'Ser-727' phosphorylation of STAT3 and regulation of its transcriptional potential.
TRUSTED_SUSTAINABILITY

Especificaciones

Antígeno Phospho-MSK1 (Thr581)
Aplicaciones ELISA, Western Blot
Clasificación Polyclonal
Concentración 0.4 mg/mL
Conjugado Unconjugated
Formulación PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
génica Rps6ka5
N.º de referencia del gen O75582, Q8C050
Alias de gen 3110005L17Rik; 6330404E13Rik; 90 kDa ribosomal protein S6 kinase 5; AI854034; kinase MSK1; KS6A5; mitogen and stress-activated protein kinase 1; Msk1; MSPK1; Nuclear mitogen- and stress-activated protein kinase 1; ribosomal protein S6 kinase A5; ribosomal protein S6 kinase alpha-5; ribosomal protein S6 kinase, 90kDa, polypeptide 5; ribosomal protein S6 kinase, polypeptide 5; RLPK; RLSK; Rps6ka5; RSKL; RSK-like protein kinase; S6K-alpha-5
Símbolos de los genes Rps6ka5
Especie del huésped Rabbit
Inmunógeno A synthetic phosphorylated peptide around T581 of human RPS6KA5 (NP_004746.2).
Método de purificación Affinity Chromatography
Cantidad 100 μL
Estado normativo RUO
Primario o secundario Primary
ID de gen (Entrez) 314384, 73086, 9252
Especies diana Human, Mouse, Rat
Contenido y almacenamiento -20°C, Avoid Freeze/Thaw Cycles
Tipo de producto Antibody
Formulario Liquid
Isotype IgG
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