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Invitrogen™ Phospho-FOXO1/FOXO3/FOXO4 (Thr24, Thr32) Polyclonal Antibody
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Código de producto. 15544031
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Cantidad:
100 μL
Tamaño de la unidad:
100 microlitros
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15544031 100 μL 100 microlitros
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Código de producto. 15544031 Proveedor Invitrogen™ N.º de proveedor PA536737

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Descripción

Rabbit Polyclonal Antibody

This antibody detects endogenous protein at a molecular weight of 70-82 kDa. Purity is >95% by SDS-PAGE.

FOXO1 + FOX3 + FOX4 belong to the forkhead family of transcription factors. FOXO1 (FKHR or ForkHead in Rhabdomyosarcoma) is a 70 kDa protein. Recent studies have shown that this protein can act as either a coactivator or a corepressor of nuclear receptor activity. This action is mediated through the LXXLL motif found in the C terminus of the FOXO1A protein. The specific function of the gene has not yet been determined.FOX3 probably functions as a trigger for apoptosis through expression of genes necessary for cell death. Translocation of the FOXO3 gene with the MLL gene is associated with secondary acute leukemia.FOX4 is a forkhead transcription factor involved in the regulation of the insulin signaling pathway. It binds to insulin-response elements (IREs) and can activate transcription of IGFBP1. FOXO4 down-regulates expression of HIF1A and suppresses hypoxia-induced transcriptional activation of HIF1A-modulated genes. It is also involved in negative regulation of the cell cycle.
TRUSTED_SUSTAINABILITY

Especificaciones

Antígeno Phospho-FOXO1/FOXO3/FOXO4 (Thr24, Thr32)
Aplicaciones Immunohistochemistry (Paraffin), Western Blot
Clasificación Polyclonal
Concentración 1 mg/mL
Conjugado Unconjugated
Formulación PBS with 50% glycerol and 0.02% sodium azide; pH 7.2
génica FOXO3
N.º de referencia del gen O43524, P98177, Q12778
Alias de gen 1110048B16Rik; 2010203A17Rik; AF6q21; AF6q21 protein; AFX; AFX1; Afxh; AI876417; C76856; FKH1; FKHR; Fkhr1; Fkhr2; Fkhr3; FKHRL1; FKHRL1P2; fork head domain transcription factor AFX1; forkhead box O1; forkhead box O1a; forkhead box O1A (rhabdomyosarcoma); forkhead box O3; forkhead box O3A; forkhead box O4; forkhead box protein O1; Forkhead box protein O1A; forkhead box protein O3; Forkhead box protein O4; forkhead homolog (rhabdomyosarcoma) like 1; forkhead in rhabdomyosarcoma; Forkhead in rhabdomyosarcoma-like 1; forkhead protein; forkhead protein 1; forkhead protein FKHR2; forkhead, Drosophila, homolog of, in rhabdomyosarcoma; forkhead, Drosophila, homolog of, in rhabdomyosarcoma-like 1; Foxo1; FOXO1A; FOXO2; FOXO3; Foxo3a; FOXO4; MGC120490; Mllt7; myeloid/lymphoid or mixed lineage-leukemia translocation to 7 homolog; myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 7; RGD1561201
Símbolos de los genes FOXO1, FOXO3, FOXO4
Especie del huésped Rabbit
Inmunógeno Synthetic phosphopeptide derived from human FoxO1 around the phosphorylation site of Threonine 24.
Método de purificación Antigen affinity chromatography
Cantidad 100 μL
Estado normativo RUO
Primario o secundario Primary
ID de gen (Entrez) 2308, 2309, 4303
Especies diana Human
Contenido y almacenamiento Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Tipo de producto Antibody
Formulario Liquid
Isotype IgG
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