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  6. Invitrogen™ Phospho-Chk2 (Thr68) Recombinant Rabbit Monoclonal Antibody (Chk2T68-D12)

Invitrogen™ Phospho-Chk2 (Thr68) Recombinant Rabbit Monoclonal Antibody (Chk2T68-D12)

Código de producto. 15927194
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Cantidad:
20 μL
200 μL
Tamaño de la unidad:
20 microlitros
200 microlitros
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15927194 200 μL 200 microlitros
17116578 20 μL 20 microlitros
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Código de producto. 15927194 Proveedor Invitrogen™ N.º de proveedor MA527988

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Descripción

Rabbit Recombinant Monoclonal Antibody

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.

CHEK2 (CHK2) is a serine/threonine kinase and a component of the DNA damage checkpoint pathway. A mutation in CHK2 has been linked to cancer. CHK2 is activated by DNA damage and phosphorylates several modulators of cell cycle control including tumor suppressor proteins. In addition, Chk2 can phosphorylate BRCA1, allowing BRCA1 to restore survival after DNA damage. Chk2 is a putative tumor suppressor protein, with mutations in to the Chk2 gene linked to Li-Fraumeni syndrome, a familiar cancer usually associated with inherited mutations in TP53. Also, mutations in CHK2 are thought to confer a predisposition to sarcomas, breast cancer, and brain tumors.
TRUSTED_SUSTAINABILITY

Especificaciones

Antígeno Phospho-Chk2 (Thr68)
Aplicaciones Flow Cytometry, Western Blot
Clasificación Recombinant Monoclonal
Clon Chk2T68-D12
Concentración 0.5 mg/mL
Conjugado Unconjugated
Formulación PBS with 0.1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.4
génica Chek2
N.º de referencia del gen O96017, Q9Z265
Alias de gen CDS1; cds1 homolog; Checkpoint kinase 2; Checkpoint like protein CHK2; checkpoint-like protein CHK2; Chek2; Chk2; Chk2 (phospho T68); Chk2 (pThr68); CHK2 checkpoint homolog; CHK2 checkpoint homolog (S. pombe); Chk2 phospho; Chk2 phospho T68; del9; EC 2.7.11.1; hCds1; HuCds 1; HuCds1; kinase Chk2; LFS2; OTTHUMP00000199044; OTTHUMP00000199045; OTTHUMP00000199064; OTTHUMP00000199115; OTTHUMP00000199116; phospho Chk2 (T68); phospho Thr68 Chk2; PP1425; protein kinase Chk2; Rad53; Rad53 homolog; RP11-436C9.1; Serine/threonine protein kinase Chk2; serine/threonine-protein kinase Chk2
Símbolos de los genes Chek2
Especie del huésped Rabbit
Inmunógeno A synthetic phospho-peptide corresponding to residues surrounding Thr68 of human phospho Chk2.
Método de purificación Protein A/G
Cantidad 200 μL
Estado normativo RUO
Primario o secundario Primary
ID de gen (Entrez) 11200, 50883
Especies diana Human, Mouse
Contenido y almacenamiento -20°C
Tipo de producto Antibody
Formulario Liquid
Isotype IgG κ
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