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Invitrogen™ Phospho-c-Raf (Tyr340, Tyr341) Polyclonal Antibody

Código de producto. 10028192
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Cantidad:
100 μL
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cada uno
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10028192 100 μL cada uno
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Product Code. 10028192 missing translation for 'mfr' Invitrogen™ missing translation for 'supplierNo' 44506G

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Description

Rabbit Polyclonal Antibody

Phospho-c-Raf (Tyr340, Tyr341) Polyclonal Antibody for Western Blot, IHC

Raf-1 (c-Raf) is a MAP kinase kinase kinase (MAP3K) which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated Raf-1 can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2 which in turn phosphorylate to activate the serine/threonine specific protein kinases ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation and cell migration. Mutations in this gene are associated with Noonan syndrome 5 and LEOPARD syndrome 2.
TRUSTED_SUSTAINABILITY

Specifications

Antígeno Phospho-c-Raf (Tyr340, Tyr341)
Aplicaciones Immunohistochemistry, Western Blot
Clasificación Polyclonal
Conjugado Unconjugated
Formulación Dulbecco's PBS with 1mg/mL BSA and 0.05% sodium azide; pH 7.3
génica Raf1
N.º de referencia del gen P04049, P11345, Q99N57
Alias de gen 6430402F14Rik; AA990557; BB129353; CMD1NN; CRAF; C-RAF; C-Raf proto-oncogene, serine/threonine kinase; Craf1; Craf1 transforming; D830050J10Rik; EC 2.7.11.1; kinase Raf1; murine leukemia viral (v-raf-1) oncogene homolog 1 (3611-MSV); murine sarcoma 3611 oncogene 1; NS5; Oncogene RAF1; OTTHUMP00000207813; OTTHUMP00000209389; proto-oncogene c-RAF; RAF; raf proto-oncogene serine/threonine protein kinase; RAF proto-oncogene serine/threonine-protein kinase; RAF1; Raf-1; Raf-1 proto-oncogene, serine/threonine kinase; sarcoma 3611 oncogene; v-Raf; v-raf-1 leukemia viral oncogene 1; vraf1 murine le; v-raf-1 murine leukemia viral oncogene homolog 1; v-raf-1 murine leukemia viral oncogene-like protein 1; v-raf-leukemia viral oncogene 1
Símbolos de los genes Raf1
Especie del huésped Rabbit
Inmunógeno The antibody was produced against a chemically synthesized phosphopeptide derived from a region of human c-Raf that contains tyrosines 340 and 341. The sequence is conserved in mouse and rat.
Método de purificación Antigen affinity chromatography
Cantidad 100 μL
Estado normativo RUO
Primario o secundario Primary
ID de gen (Entrez) 110157, 24703, 5894
Especies diana Human, Mouse, Rat
Contenido y almacenamiento -20°C
Tipo de producto Antibody
Formulario Liquid
Isotype IgG
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