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Tocris Bioscience™ PDD 00017273
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Código de producto. 18749356
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Cantidad:
10 mg
Tamaño de la unidad:
10 miligramos
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18749356 10 mg 10 miligramos
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Código de producto. 18749356 Proveedor Tocris Bioscience™ N.º de proveedor 5952/10

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Descripción

Potent and selective poly (ADP ribose) glycohydrolase (PARG) inhibitor; cell permeable

PDD 00017273 is a potent and selective poly (ADP ribose) glycohydrolase (PARG) inhibitor (IC50 = 26 nM). Exhibits >350-fold selectivity for PARG over a panel of ion channels, enzymes and receptors, including PARP1 and ARH3. Maintains PAR chains and induces DNA double-stranded breaks in cells following DNA damage. Decreases colony formation of ZR-75-1 BRCA1 WT cells and inhibits cancer cell survival. Cell permeable.
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Especificaciones

Nombre del producto químico o material 1-[(1,3-Dimethyl-1H-pyrazol-5-yl)methyl]-1,2,3,4-tetrahydro-N-(1-methylcyclopropyl)-3-[(2-methyl-5-thiazolyl)methyl]-2,4-dioxo-6-quinazolinesulfonamide
CAS 1945950-21-9
Cantidad 10 mg
Solubilidad Soluble to 100mM in water and to 100mM in DMSO
Objetivo PARG Inhibitors
Fórmula molecular C23H26N6O4S2
Formula Weight (peso de la fórmula) 514.62
Forma física Sólido
Color Blanco
Tipo de producto Bioactive Small Molecule
Pureza >98%
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