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Gibco™ Mouse NGF 7S Subunit Native Protein

Product Code. 11508876 Shop All Gibco Products
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Cantidad:
100 μg
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paquete de 100
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11508876 100 μg paquete de 100
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 Artículo restringido
Fecha estimada de envoi: 10-09-2026
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Description

Native Protein

Reconstitution: Reconstitute murine natural NGF 7S to a stock concentration of 100 μg/mL with 1 mL of sterile culture medium containing 1-2% (w/v) BSA. Aliquot into single-use portions in polypropylene vials and store at -20°C to avoid repeated freeze/thaw cycles. Do not store in dilute solution. Dilute immediately before use. To avoid loss of protein or activity, prepare dilute solutions in appropriate buffer or medium containing at least 0.1% (w/v) BSA or 1-10% (v/v)serum. Carrier protein (BSA or serum) is needed to stabilize the NGF protein.

Nerve growth factor (NGF) influences the survival and differentiation of a variety of neuronal and nonneuronal cells. The actions of this polypeptide result from binding to specific cell surface receptors which are present as both high and low affinity sites. Although both types of receptor bind NGF only the high affinity form is capable of signal transduction. Cross-linking studies with 125I-NGF have shown that the high affinity receptor of rat PC12 cells forms an Mr 158,000 complex with NGF while the low affinity receptor forms an Mr 100,000 complex. Full length cDNA clones for both the human and rat NGF receptor genes have been produced and sequenced, revealing greater than 90% homology between the two species. NGF exhibits nerve growth stimulating activity and is involved in the regulation of growth and the differentiation of sympathetic and certain sensory neurons. Further, NGF stimulates division and differentiation of sympathetic and embryonic sensory neurons. Mutations in the NGF gene have been associated with hereditary sensory and autonomic neuropathy, type 5 (HSAN5), and dysregulation of NGF gene expression is associated with allergic rhinitis.
TRUSTED_SUSTAINABILITY

Specifications

Número de acceso P01139
Para utilizar con (aplicación) Bioactivity
Formulación Potassium phosphate with no preservative
ID de gen (Entrez) 18049
Nombre Mouse NGF 7S Subunit
Método de purificación Purified
Cantidad 100 μg
Requisitos de almacenamiento -20°C
Estado normativo RUO
Alias de gen B nerve growth factor; beta ngf; beta-nerve growth factor; BetaNGF; beta-NGF; bNGF; b-NGF; HSAN5; MGC161426; MGC161428; Nerve growth factor; nerve growth factor (beta polypeptide); nerve growth factor, beta; nerve growth factor, beta polypeptide; nerve growth factor, beta subunit; NGF; NGF b; NGF β; Ngfb; NGFbeta; NGFβ; β nerve growth factor; β NGF; βNGF
Nombre común NGF
Símbolo de gen NGF
Actividad biológica ED50 = 5 - 100 ng/mL; determined by the dose-dependent neurite outgrowth of chick embryo dorsal root ganglia.
Tipo de producto Protein
Conjugado Unconjugated
Especie Mouse
Contenido y almacenamiento -20°C
Actividad ED50 = 5 - 100 ng/mL; determined by the dose-dependent neurite outgrowth of chick embryo dorsal root ganglia.
Condiciones de envío Dry Ice
Familia de proteínas Growth Factors & Receptors
Forma de proteína Native, Ligand
Formulario Lyophilized
Subtipo de proteína Neurotrophic Factors
Categoría de investigación Neurobiology, Signal Transduction, Oncology, Stem Cell Research, Inflammation, Differentiation, Cardiovascular Research
Grado de pureza o calidad >95% by SDS-PAGE
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