missing translation for 'onlineSavingsMsg'
Learn More
  1. Home
  2. Products
  3. Reactivos bioquímicos
  4. Proteins and Derivatives
  5. Proteínas nativas y derivadas
  6. 11514516

Gibco™ Mouse EGF Native Protein

Código de producto. 11514516
Change view
Click to view available options
Cantidad:
100 μg
Unit Size:
100 microgramos
1 product options available for selection
Product selection table with 1 available options. Use arrow keys to navigate and Enter or Space to select.
Product Code. Cantidad unitSize
11514516 100 μg 100 microgramos
Use arrow keys to navigate between rows. Press Enter or Space to select a product option. 1 options available.
1 options
This item is not returnable. View return policy
Product Code. 11514516 Supplier Gibco™ Supplier No. 53003018

Por favor, para comprar este producto. ¿No tiene usuario web? Regístrese hoy mismo.

This item is not returnable. View return policy

Description

Native Protein

Reconstitution: Reconstituted EGF should be aliquoted and stored in polypropylene vials and is stable at -5°C to -20°C for up to two months. Avoid repeated freezing and thawing. Stability of dilute solutions of EGF may be prolonged by addition of bovine serum albumin to a final concentration of 1.0%. This natural preparation of murine epidermal growth factor (EGF) was isolated from male mouse submaxillary glands. It is not sterile as provided.

EGF (Epidermal growth factor) exerts its actions by binding to the EGF Receptor, a 170 kDa protein kinase. Activation of EGFR initiates diverse cellular pathways in response to toxic environmental stimuli, or to EGF binding to the receptor, the EGFR forms homo- or heterodimers with other family members. Each dimeric receptor complex initiates a distinct signaling pathway by recruiting different Src homology 2 (SH2) containing effector proteins. EGF is far and wide expressed in kidney, cerebrum, prostrate and salivary glands. EGF acts as a potent mitogenic factor and the phosphorylated receptor recruits adapter proteins like GRB2 that activates complex downstream signaling cascades. EGF activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STAT modules. Research studies suggest the protein may also play important role in activating the NF-kappa-B signaling cascade. Defects in the EGGF gene are the cause of hypomagnesemia type 4 and dysregulation has been associated with the growth and progression of certain cancers.
TRUSTED_SUSTAINABILITY

Specifications

Número de acceso P01132
Para utilizar con (aplicación) Bioactivity
Formulación Protein with no preservative
ID de gen (Entrez) 13645
Peso molecular 6 kDa
Nombre Mouse EGF
Método de purificación Purified
Cantidad 100 μg
Requisitos de almacenamiento -20°C
Estado normativo RUO
Alias de gen AI790464; beta-urogastrone; EGF; Epidermal growth factor; epidermal growth factor (beta-urogastrone); epidermal growth factor precursor; H-EGF; HOMG4; Pro-epidermal growth factor; Pro-epidermal growth factor precursor (EGF); sb:eu639; URG; Urogastrone
Nombre común EGF
Símbolo de gen EGF
Tipo de producto Protein
Conjugado Unconjugated
Especie Mouse
Contenido y almacenamiento -20°C
Condiciones de envío Approved for shipment at Room Temperature or on Wet or Dry Ice
Familia de proteínas Growth Factors & Receptors
Forma de proteína Native, Ligand
Formulario Lyophilized
Subtipo de proteína EGF (Epidermal Growth Factor)
Categoría de investigación Neurobiology, Stem Cell Research, Differentiation, Oncology
Grado de pureza o calidad >95% by SDS-PAGE
Show More Show Less
Product Title
Select an issue

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.