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Descripción
MKNK1 encodes a predicted 424-amino acid protein containing a sequence typical of the catalytic domain of serine/threonine kinases and a putative N-terminal nuclear localization signal sequence. C-terminal region of MKNK1 was phosphorylated and activated in vivo and in vitro by ERK1 and p38 MAP kinases, but not by JNK/SAPK. The activated ERK is essential for the activation of MKNK1 in insect cells. MKNK1 was activated following stimulation of HeLa cells with a variety of extracellular stimuli. MNK1 bind tightly to the growth factor-regulated MAP kinases, Erk1 and Erk2, and also binds strongly to the stress-activated kinase, p38.
Especificaciones
Especificaciones
| Antígeno | MNK1 |
| Aplicaciones | Immunocytochemistry, Western Blot, Immunofluorescence |
| Clasificación | Polyclonal |
| Concentración | 0.15 mg/mL |
| Conjugado | Unconjugated |
| Formulación | PBS with 50% glycerol and 0.1% sodium azide; pH 7.3 |
| génica | MKNK1 |
| N.º de referencia del gen | O08605, Q4G050, Q9BUB5 |
| Alias de gen | MKNK1, MNK1 |
| Símbolos de los genes | Mknk1 |
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