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Invitrogen™ MMP15 Polyclonal Antibody

Descripción
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
MMPs are a group of enzymes involved in matrix degradation. Of the sixteen members of matrix metalloproteinase family ten exist in soluble form whereas MT-MMPs exist as integral membrane proteins. MT1-MMP, MT2-MMP, MT3-MMP also known as MMP14, MMP15, MMP16 respectively contain a C-terminal transmembrane domain anchoring them to the cell surface. They have an 8 amino acid insert in their catalytic domain. MT1-MMP cleaves progelatinase A (MMP-2) and progelatinase B to their active forms. MT2-MMP plays a minor role in activation of pro-MMP-2 to its active form in breast carcinomas. Coexpression of MT1-MMP and MT2-MMp in advanced stages of breast carcinomas is indicative of possible involvement of MT2-MMP in its metastasis.
Especificaciones
Especificaciones
| Antígeno | MMP15 |
| Aplicaciones | Western Blot |
| Clasificación | Polyclonal |
| Concentración | 1 mg/mL |
| Conjugado | Unconjugated |
| Formulación | PBS with 0.05% sodium azide; pH 7.2 |
| génica | Mmp15 |
| N.º de referencia del gen | O54732, P51511 |
| Alias de gen | AI503551; matrix metallo protease; matrix metallopeptidase 15; matrix metallopeptidase 15 (membrane-inserted); matrix metalloproteinase 15; matrix metalloproteinase 15 (membrane-inserted); matrix metalloproteinase-15; Membrane type 2-MMP; membrane-type matrix metalloproteinase 2; Membrane-type-2 matrix metalloproteinase; MMP; Mmp15; MMP-15; MMPs; MT2MMP; MT2-MMP; MT-MMP 2; MTMMP2; SMCP-2 |
| Símbolos de los genes | Mmp15 |
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Título del producto
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