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Invitrogen™ MICA/B Monoclonal Antibody (6D4), Biotin
Mouse Monoclonal Antibody
Marca: Invitrogen™ MA538726
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Descripción
This antibody recognizes a common extracellular epitope on MICA and MICB glycoproteins, transmembrane ligands of CD314 (NKG2D), and is able to block CD314-mediated activation of NK cells and cytotoxic T cells.
MICA encodes the higly polymorphic MHC (HLA) class I chain-related gene A. The protein product is expressed on the cell surface, although unlike canonical class I molecules does not seem to associate with beta-2-microglobulin. It is thought that MICA functions as a stress-induced antigen that is broadly recognized by intestinal epithelial gamma delta T cells.
Especificaciones
| MICA/B | |
| Monoclonal | |
| 1 mg/mL | |
| PBS with 15 mM sodium azide; pH 7.4 | |
| Q29980, Q29983 | |
| MICA, MICB | |
| Transfected C1R cells expressing MICA. | |
| 100 μg | |
| Primary | |
| Human | |
| Antibody | |
| IgG2a |
| Flow Cytometry, Immunoprecipitation, Immunocytochemistry | |
| 6D4 | |
| Biotin | |
| MICA | |
| HLA class I antigen; MHC class I chain-related protein A; MHC class I chain-related protein B; MHC class I mic-B antigen; MHC class I polypeptide-related sequence A; MHC class I polypeptide-related sequence B; MHC class I related sequence A; MHC class I-like molecule PERB11.2-IMX; MICA; MIC-A; MICB; MIC-B; PERB11.1; PERB11.2; sMICA; sMICB; soluble MICA; soluble MICB; stress inducible class I homolog; truncated MHC class I polypeptide-related sequence A | |
| Mouse | |
| Size-exclusion chromatography | |
| RUO | |
| 100507436, 4277 | |
| 4°C, do not freeze | |
| Liquid |
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