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Invitrogen™ MFN1 Polyclonal Antibody

Descripción
Positive Samples: A-549, LO2, SW480, Mouse liver, Mouse kidney; Cellular Location: Cytoplasm, Mitochondrion outer membrane, Multi-pass membrane protein Immunogen sequence: YGALYLYERL SWTTHAKERA FKQQFVNYAT EKLRMIVSST SANCSHQVKQ QIATTFARLC QQVDITQKQL EEEIARLPKE IDQLEKIQNN SKLLRNKAVQ LENELENFTK QFLPSSNEES.
Mitofusin 1 (MFN1) and the related protein MFN2 are mitochondrial membrane GTPase proteins that play a central role in mitochondrial metabolism and may be associated with obesity and/or apoptosis processes. MFN1 and MFN2 form homotypic and heterotypic complexes and coordinately regulate mitochondrial fusion and are essential for embryonic development. When ectopically expressed, MFN1 inhibits the apoptosis-associated amino-terminal conformation change in the apoptotic protein Bax but not its mitochondrial translocation, indicating that MFN1 is involved in the regulating the activation of Bax on the outer mitochondrial membrane.
Especificaciones
Especificaciones
| Antígeno | MFN1 |
| Aplicaciones | ELISA, Western Blot, Immunocytochemistry |
| Clasificación | Polyclonal |
| Concentración | 3.78 mg/mL |
| Conjugado | Unconjugated |
| Formulación | PBS with 50% glycerol and 0.05% ProClin 300; pH 7.3 |
| génica | MFN1 |
| N.º de referencia del gen | Q811U4, Q8IWA4, Q8R4Z9 |
| Alias de gen | 2310002F04Rik; 6330416C07Rik; D3Ertd265e; DKFZp762F247; EC 3.6.5; FLJ20693; Fzo homolog; Fzo1b; hfzo1; hfzo2; HR2; Mfn1; MFN2; MGC41806; mitochondrial mitofusin 1; mitochondrial transmembrane GTPase Fzo-1; mitochondrial transmembrane GTPase FZO1B; mitochondrial transmembrane GTPase FZO-2; mitofusin 1; mitofusin 2; mitofusin-1; mKIAA4032; putative transmembrane GTPase; transmembrane GTPase MFN1 |
| Símbolos de los genes | MFN1 |
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Título del producto
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