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  5. Tocris Bioscience™ Mdivi 1

Tocris Bioscience™ Mdivi 1
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Código de producto. 18086062
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Cantidad:
10 mg
50 mg
Tamaño de la unidad:
10 miligramos
50 miligramos
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Código de producto. Cantidad unitSize
18086062 50 mg 50 miligramos
18084462 10 mg 10 miligramos
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Product Code. 18086062 Supplier Tocris Bioscience™ Supplier No. 3982/50

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Description

Selective dynamin inhibitor; attenuates mitochondrial division and apoptosis

Mdivi 1 is a selective inhibitor of dynamin GTPase (IC50 = 1 - 10 μM); attenuates Dnm1- and Drp1-mediated mitochondrial division. Mdivi 1 inhibits mitochondrial outer membrane permeabilization (MOMP) and attenuates apoptosis. In cancer cell lines, Mdivi 1 reduces cell proliferation; in an animal model of ischemic retina Mdivi 1 treatment blocks apoptosis. In a cell model, Mdivi 1 protects against mutant huntington-induced damage and mitochondrial dysfunction. Mdivi 1 also inhibits autophagy and protects neurons from excitotoxicity.
TRUSTED_SUSTAINABILITY

Chemical Identifiers

CAS 338967-87-6
Fórmula molecular C15H10Cl2N2O2S

Specifications

Nombre del producto químico o material Dynamin Inhibitors
Cantidad 50 mg
Formula Weight (peso de la fórmula) 353.22
Pureza >98%
Peso molecular 353.217
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