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  5. Tocris Bioscience™ LY 2109761

Tocris Bioscience™ LY 2109761
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Código de producto. 18736075
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Cantidad:
10 mg
50 mg
Tamaño de la unidad:
10 miligramos
50 miligramos
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18736075 50 mg 50 miligramos
18715795 10 mg 10 miligramos
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Código de producto. 18736075 Proveedor Tocris Bioscience™ N.º de proveedor 7864/50

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Description

Selective TGF-β kinase inhibitor

LY 2109761 is a selective dual TGF-β receptor type I and II (TβRI/II) inhibitor (Ki values are 38 and 300 nM in a cell-free assay, respectively); it inhibits the kinase activity of both TGF-βRI and TGF-βRII. In vitro, it significantly inhibits the growth, motility, and invasiveness of L3.6pl/GLT pancreatic cancer cells and completely suppresses TGF-β-induced Smad2 phosphorylation. In vivo, LY 2109761, in combination with Gemcitabine, significantly reduces tumor volume and spontaneous abdominal metastases in a murine model of metastatic pancreatic cancer. LY 2109761 is orally bioavailable.
TRUSTED_SUSTAINABILITY

Specifications

Nombre del producto químico o material 4-[5,6-Dihydro-2-(2-pyridinyl)-4 H-pyrrolo[1,2-b]pyrazol-3-yl]-7-[2-(4-morpholinyl)ethoxy]quinoline
CAS 700874-71-1
Cantidad 50 mg
Objetivo TGF-beta Receptor Inhibitors
Fórmula molecular C26H27N5O2
Pureza 0.98
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