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Invitrogen™ LRP5 Monoclonal Antibody (2B11)
Descripción
MA5-17113 targets LRP5 in FACS, indirect ELISA, and WB applications and shows reactivity with Human samples. The MA5-17113 immunogen is purified recombinant fragment of human LRP5 expressed in E. Coli. MA5-17113 detects LRP5 which has a predicted molecular weight of approximately 179kDa.
LDL related proteins, LRP 5 and LRP 6, are members of the LDL receptor superfamily, which were found to be involved in the canonical Wnt signaling pathway. Mammalian LRP 6 was shown to bind to Wnt 1 and enhance Wnt-induced developmental processes in Xenopus embryos. Mice lacking LRP 6 exhibited developmental defects that are similar to those caused by deficiencies in various Wnt proteins. Recent work also shows that Wnt proteins induce the binding of LRP 5 to Axin, leading Axin degradation and beta catenin stabilization.
Especificaciones
Especificaciones
| Antígeno | LRP5 |
| Aplicaciones | ELISA, Flow Cytometry, Western Blot |
| Clasificación | Monoclonal |
| Clon | 2B11 |
| Concentración | 1 mg/mL |
| Conjugado | Unconjugated |
| Formulación | PBS with 0.05% sodium azide |
| génica | LRP5 |
| N.º de referencia del gen | O75197 |
| Alias de gen | BMND1; EVR1; EVR4; HBM; HGNC:6697; LDL receptor related protein 5; low density lipoprotein receptor-related protein 5; low density lipoprotein receptor-related protein 7; low-density lipoprotein receptor-related protein 5; Low-density lipoprotein receptor-related protein 7; LR3; Lrp5; LRP-5; LRP7; LRP-7; mKIAA4142; OPPG; OPS; OPTA1; VBCH2 |
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Título del producto
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