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Invitrogen™ LDHA Polyclonal Antibody
Rabbit Polyclonal Antibody
Marca: Invitrogen™ PA519754
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Descripción
Heat mediated antigen retrieval recommended prior to tissue staining. This antibody is predicted to react with mouse, rat, rabbit, chimpanzee and chinese hamster based on sequence homology.
Lactate dehydrogenase (LDH) is the enzyme in the glycolytic pathway that converts pyruvate to lactate with concomitant interconversion of NADH and NAD+. In mammals, the enzyme is encoded by three genes: LDHA (M or muscle form), LDHB (H or heart form), and LDHC (X or testis form). The three human LDHs have 84-89% sequence similarities and 69-75% amino acid identities. There are five different LDH isoenzymes based on the proportion of M and H chains existing in the LDH tetrameric structure. The LDHA is hypoxia inducible and its expression is directly controlled by the transcriptional activity of the hypoxia inducible factor 1a (HIF1a). LDHB is also known to be upregulated in many cancers. Mutations in the LDHA gene can lead to Glycogen storage disease 11 (GSD11).
Especificaciones
| LDHA | |
| Polyclonal | |
| Unconjugated | |
| LDHA | |
| Cell proliferation-inducing gene 19 protein; epididymis secretory sperm binding protein Li 133P; GSD11; HEL-S-133P; l7R2; Lactate Dehydrogenase; lactate dehydrogenase 1, A chain; lactate dehydrogenase 3, C chain, sperm specific; lactate dehydrogenase A; lactate dehydrogenase A4; lactate dehydrogenase A-like; lactate dehydrogenase C; lactate dehydrogenase C variant 3; lactate dehydrogenase M; lactate dehydrogenase-A; lactate dehydrogenase-M; lactate dehydrogenase-M (EC 1.1.1.27); Lactic Dehydrogenase; LDH; LDH muscle subunit; LDH testis subunit; Ldh1; Ldh-1; Ldh3; Ldha; LDH-A; ldha protein; ldha1; LDH-A4 muscle-specific isozyme; glycolytic enzyme; Ldhc; LDH-C; Ldhm; LDH-M; LDH-X; L-lactate dehydrogenase; L-lactate dehydrogenase A chain; L-lactate dehydrogenase C chain; M-LDH; OTTHUMP00000165206; PIG19; proliferation-inducing gene 19; renal carcinoma antigen NY-REN-59 | |
| Rabbit | |
| Antigen Affinity Chromatography | |
| RUO | |
| 3939 | |
| Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
| Liquid |
| Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot, Immunocytochemistry | |
| 0.9 mg/mL | |
| PBS with 1% BSA and 0.02% sodium azide; pH 7.4 | |
| P00338 | |
| LDHA | |
| Synthetic peptide conjugated to KLH derived from within residues 300 to the C-terminus of Human Lactate Dehydrogenase. | |
| 100 μg | |
| Primary | |
| Human | |
| Antibody | |
| IgG |
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