missing translation for 'onlineSavingsMsg'
Learn More
Learn More
Tocris Bioscience™ JTE 607 Dihydrochloride
Active metabolite binds CPSF3; Pro-drug
Marca: Tocris Bioscience™ 5185/50
Este artículo no se puede devolver.
Vea la política de devoluciones
Descripción
JTE 607 is a pro-drug that is cleaved by carboxylesterase 1 (CES1) to its active metabolite, which then binds to cleavage and polyadenylation specificity factor 3 (CPSF3; Kd = 370 nM at human CPSF3). Treatment of A-673 cells with JTE 607 results in inhibition of mRNA cleavage and accumulation of nuclear R-loops. JTE 607 induces apoptosis in leukemia cells in vitro and prolongs survival in a mouse leukemia model.JTE 607 also inhibits cytokine release; it inhibits production of IL-1β, IL-8, IL-6, IL-10 and TNFα (IC50 values are 5.9, 7.3, 8.8, 9.1 and 11.0 nM, respectively) from LPS-stimulated PBMCs. In a rat model of lung injury, JTE 607 reduces proinflammatory cytokine-release and attenuates lung permeability.
Especificaciones
| JTE 607 dihydrochloride | |
| N-[3,5-Dichloro-2-hydroxy-4-[2-(4-methyl-1-piperazinyl)ethoxy]benzoyl]-L-phenylalanine ethyl ester dihydrochloride | |
| Soluble to 100mM in water and to 100mM in DMSO | |
| Bioactive Small Molecule |
| 188791-09-5 | |
| 50 mg | |
| Solid |
Título del producto
Al hacer clic en Enviar, acepta que Fisher Scientific se ponga en contacto con usted en relación con los comentarios que ha proporcionado en este formulario. No compartiremos su información para ningún otro fin. Toda la información de contacto proporcionada se mantendrá de acuerdo con nuestra Política de Privacidad. Política de privacidad.
¿Detecta una oportunidad de mejora?
Research Use Only. Not For Human or Veterinary Use