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Indomethacin, 99+%

Product Code. 15435529
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5 g
25 g
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25 g
5 g
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15435529 5 g 5 g
15425529 1 g 1 g
15445529 25 g 25 g
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Product Code. 15435529 Supplier Thermo Scientific Alfa Aesar Supplier No. J63255.06
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Description

Indomethacin, CAS # 53-86-1, is an indole-based nonsteroidal anti-inflammatory (NSAID). | CAS: 53-86-1 | C19H16ClNO4 | 357.79 g/mol

Non-selective cyclooxygenase inhibitorIndomethacin acts as an antiinflammatory, antipyretic and analgesic. It serves as an inhibitor cyclooxygenase such as Cox-1 and Cox-2. In addition to this, it is used as a prescription medication in order to reduce fever, stiffness, swelling and pain.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

  • Indomethacin is a synthetic NSAID of the indole family that inhibits cyclooxygenase and reduces prostaglandin and pyrogen release
  • Indomethacin may suppress the multi-drug resistant transporter and thereby increase the efficacy of antineoplastics
  • Indomethacin activates phosphatases that inhibit signaling pathways associated with cancer cell migration and proliferation

Applications

  • Indomethacin may be used for the laboratory study of cancer cell proliferation, tumorigenesis and drug interactions
  • Indomethacin may be used for laboratory study of the effect of inhibiting the multi-drug resistance transporter, or for downregulation of survival signaling in cells via survivin
TRUSTED_SUSTAINABILITY

Chemical Identifiers

CAS 53-86-1
Fórmula molecular C19H16ClNO4
Peso molecular (g/mol) 357.79
Número MDL MFCD00057095
Clave InChI CGIGDMFJXJATDK-UHFFFAOYSA-N
Sinónimo indomethacin, indometacin, indocin, indometacine, indomethacine, indocid, metindol, amuno, indomethazine, imbrilon
PubChem CID 3715
ChEBI CHEBI:49662
Nombre IUPAC ácido 2-[1-(4-clorobenzoil)-5-metoxi-2-metilindol-3-il]acético
SMILES CC1=C(C2=C(N1C(=O)C3=CC=C(C=C3)Cl)C=CC(=C2)OC)CC(=O)O

Specifications

Nombre del producto químico o material Indomethacin
Punto de fusión 158°C to 161°C
Color Blanco
Cantidad 5 g
Número UN UN2811
Beilstein 497341
Sensibilidad Light sensitive
Índice Merck 14,4968
Información de solubilidad Soluble in ethanol and dimethyl sulfoxide.
Formula Weight (peso de la fórmula) 357.8
Porcentaje de pureza ≥99%
Forma física Powder
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Safety and Handling

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Product Identifier
  • Indomethacin
 Signal Word
  • Peligro
 Hazard Category
  • Toxicidad aguda Categoría 2
  • Toxicidad para la reproducción Categoría 1B
  • Sensibilización cutánea Categoría 1
 Hazard Statement
  • H300-Mortal en caso de ingestión.
  • H317-Puede provocar una reacción alérgica en la piel.
  • H360FD-Puede perjudicar a la fertilidad. Puede dañar al feto.
 Precautionary Statement
  • P201-Pedir instrucciones especiales antes del uso.
  • P280-Llevar guantes/prendas/gafas/máscara de protección.
  • P301+P330+P331-EN CASO DE INGESTIÓN: Enjuagarse la boca. NO provocar el vómito.
  • P302+P352-EN CASO DE CONTACTO CON LA PIEL: Lavar con abundante agua/.
  • P308+P313-EN CASO DE exposición manifiesta o presunta: Consultar a un médico.
  • P405-Guardar bajo llave.
 Supplemental information
  • MIXTURE LIST-Contain: Indomethacin
SDS

RUO – Research Use Only

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