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Glibenciclamida, 99 %, Thermo Scientific Chemicals

Product Code. 11456974
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Product Code. 11456974 Supplier Thermo Scientific Alfa Aesar Supplier No. B21459.14
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Description

CAS: 10238-21-8 | C23H28ClN3O5S | 494.003 g/mol

Glyburide (Glibenclamide) is a sulfonylurea compound that modulates insulin production. Sulfonylureas bind to ATP-dependent K+ channels in beta cells of the pancreas, depolarizing them and stimulating the release of Ca2+, which in turn stimulates insulin production. Glyburide (Glibenclamide) is an ATP-dependent K+ channel (KIR6, KATP) and CFTR Cl- channel blocker. This compound inhibits recombinant CFTR Cl- channels (IC50 = 20 M).

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Aplicaciones
La gliburida (glibenclamida) es un compuesto de sulfonilurea que modula la producción de insulina. Las sulfonilureas se unen a los canales de K+ dependientes de ATP en las células beta del páncreas, despolarizándolos y estimulando la liberación de Ca2+, que a su vez estimula la producción de insulina. La gliburida (glibenclamida) es un canal de K+ dependiente de ATP (KIR6, KATP) y un bloqueador de los canales de cloro CFTR. Este compuesto inhibe los canales de cloro CFTR recombinantes (IC50 = 20 μm).

Solubilidad
Soluble en etanol (5 mg/ml), DMSO (25 mg/ml), cloroformo (1:36), metanol (1:250) y DMF. Insoluble en agua.

Notas
Almacenar en un lugar fresco. Mantenga el recipiente bien cerrado en un lugar seco y bien ventilado. Temperatura de almacenamiento recomendada: 2-8 °C. Mantener lejos de agentes oxidantes fuertes.
TRUSTED_SUSTAINABILITY

Chemical Identifiers

CAS 10238-21-8
Fórmula molecular C23H28ClN3O5S
Peso molecular (g/mol) 494.003
Número MDL MFCD00056625
Clave InChI ZNNLBTZKUZBEKO-UHFFFAOYSA-N
Sinónimo glyburide, glibenclamide, glybenclamide, micronase, diabeta, glynase, daonil, euglucon, maninil, semi-daonil
PubChem CID 3488
ChEBI CHEBI:5441
Nombre IUPAC 5-cloro-N-[2-[4-(ciclohexilcarbamoilsulfamoil)fenil]etil]-2-metoxibenzamida
SMILES COC1=C(C=C(C=C1)Cl)C(=O)NCCC2=CC=C(C=C2)S(=O)(=O)NC(=O)NC3CCCCC3

Specifications

Nombre del producto químico o material Glybenzcyclamide
Punto de fusión 171°C to 174°C
Cantidad 25 g
Información de solubilidad Soluble in ethanol (5mg/mL),DMSO (25mg/mL),chloroform (1:36),methanol (1:250),and DMF. Insoluble in water.
Formula Weight (peso de la fórmula) 494.01
Porcentaje de pureza 99%

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