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Glimepiride

Código de producto. 15484489
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Cantidad:
100 mg
1 g
Tamaño de la unidad:
1 g
100 miligramos
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Código de producto. Cantidad Tamaño de la unidad
15484489 100 mg 100 miligramos
15474489 1 g 1 g
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Código de producto. 15484489 Proveedor Thermo Scientific Alfa Aesar N.º de proveedor J62032.MC
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Descripción

A sulfonylurea hypoglecemic agent and potent potassium channel blocker | CAS: 93479-97-1 | C24H34N4O5S | 490.62 g/mol

Glimepiride induces the PI3 kinase (PI3K) and Akt pathway, along with insulin receptor substrate-1/2 and endothelial nitric oxide synthase. Glimepiride also increases osteoblast proliferation and differentiation, which is thought to be related to its ability to activate the PI3K and Akt pathway. Furthermore, Glimepiride enhances intrinsic peroxisome proliferator-activated receptor γ activity. Glimepiride also increases protein expression of glucose transports 1 and 4, and is a potent KIR channel blocker. Potent Kir6 (KATP) channel blocker and anti-diabetic agent. Inhibits pinacidil-activated cardiac Kir6 channels with an IC50 of 6.8 nM.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
Glimepiride induces the PI3 kinase (PI3K) and Akt pathway, along with insulin receptor substrate-1/2 and endothelial nitric oxide synthase. Glimepiride also increases osteoblast proliferation and differentiation, which is thought to be related to its ability to activate the PI3K and Akt pathway. Furthermore, Glimepiride enhances intrinsic peroxisome proliferator-activated receptor γ activity. Glimepiride also increases protein expression of glucose transports 1 and 4, and is a potent KIR channel blocker. Potent Kir6 (KATP) channel blocker and anti-diabetic agent. Inhibits pinacidil-activated cardiac Kir6 channels with an IC50 of 6.8 nM.

Solubility
Soluble in DMSO

Notes
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Keep away from strong oxidizing agents.
TRUSTED_SUSTAINABILITY

Identificadores de productos químicos

CAS 93479-97-1
Fórmula molecular C24H34N4O5S
Peso molecular (g/mol) 490.62
Número MDL MFCD00878417
Clave InChI WIGIZIANZCJQQY-UHFFFAOYSA-N
Sinónimo glimepiride, amaryl, glimepiridum, glimepirida, amarel, glimepirid, glimepride, endial, roname, glimepiridum latin
PubChem CID 3476
Nombre IUPAC 3-ethyl-4-methyl-N-{2-[4-({[(4-methylcyclohexyl)carbamoyl]amino}sulfonyl)phenyl]ethyl}-2-oxo-2,5-dihydro-1H-pyrrole-1-carboxamide
SMILES CCC1=C(C)CN(C(=O)NCCC2=CC=C(C=C2)S(=O)(=O)NC(=O)NC2CCC(C)CC2)C1=O

Especificaciones

Nombre del producto químico o material Glimepiride
Punto de fusión 212°C to 215°C
Color Blanco
Cantidad 100 mg
Índice Merck 14,4440
Información de solubilidad Soluble in DMSO
Formula Weight (peso de la fórmula) 490.62
Forma física Powder

RUO – Research Use Only

Título del producto
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