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  5. STEMCELL Technologies Geldanamycin

STEMCELL Technologies Geldanamycin

Código de producto. 17140312
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Cantidad:
1 mg
5 mg
Tamaño de la unidad:
1 miligramo
5 miligramos
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Código de producto. 17140312 Proveedor STEMCELL Technologies N.º de proveedor 74032

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Descripción

Inhibits Hsp90

  • Geldanamycin is a benzoquinone ansamycin antibiotic that selectively inhibits heat shock protein 90 (Hsp90) (Schulte et al.; Whitesell et al.) It inhibits the ATPase activity of Hsp90 by binding with high affinity to the N-terminal ATP-binding site (Kd = 1.2 μM; Roe et al.) Geldanamycin also binds to the glucose-regulated protein GRP94, an endoplasmic reticulum protein with homology to Hsp90
  • This interaction destabilizes its complex with p185-ERBB2 leading to degradation of ERBB2 protein, which is overexpressed in aggressive breast cancers (Chavany et al.; Castagnola et al.)
  • Inhibits growth of 60 human tumor cell lines (Supko et al.)
  • Regulates innate immune response as demonstrated by inhibition of inflammasome activity in a mouse gout model (Mayor et al.)
  • Inhibits replication of HSV-1 and HSV-2 (Li et al.)

Tekniske data

CAS 30562-34-6
Sinónimo NSC 122750
Cantidad 1 mg
Fórmula molecular C29H40N2O9
Pureza ≥98%
Produkttitel
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