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  5. Tocris Bioscience™ Galunisertib

Tocris Bioscience™ Galunisertib
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Código de producto. 18777976
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Cantidad:
5 mg
25 mg
Tamaño de la unidad:
25 miligramos
5 miligramos
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Código de producto. Cantidad unitSize
18777976 5 mg 5 miligramos
18779136 25 mg 25 miligramos
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Código de producto. 18777976 Proveedor Tocris Bioscience™ N.º de proveedor 6956/5

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Descripción

ALK4 and ALK5 (TGFβRI) inhibitor

Galunisertib is an ALK4 and ALK5 (TGFβRI) inhibitor (IC50 values are 77.7 and 172 nM, respectively). Also inhibits a range of other kinases with submicromolar IC50s including MINK, TGFβRII, ALK6 and ACVR2B. Inhibits TGFβ-induced SMAD phosphorylation in cancer cell lines in vitro and in vivo. Also reverses TGFβ-mediated suppression of T cell proliferation. Prevents TGFβ-mediated EMT and cell migration in vitro and exhibits antitumor efficacy in vivo. Used as component of growth media for urothelial organoids. Orally bioavailable.
TRUSTED_SUSTAINABILITY

Specifications

Nombre del producto químico o material 4-[5,6-Dihydro-2-(6-methyl-2-pyridinyl)-4 H-pyrrolo[1,2-b]pyrazol-3-yl]-6-quinolinecarboxamide
CAS 700874-72-2
Cantidad 5 mg
Objetivo TGF-beta Receptor Inhibitors
Fórmula molecular C22H19N5O
Formula Weight (peso de la fórmula) 369.43
Tipo de producto Inhibitor
Pureza 98%
Product Title
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