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Etoposide

Código de producto. 15495819
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Código de producto. 15495819 Proveedor Thermo Scientific Alfa Aesar N.º de proveedor J63651.MB
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Descripción

Topoisomerase inhibitor and inducer of apoptosis | CAS: 33419-42-0 | C29H32O13 | 588.56 g/mol

Etoposide is used as a inhibits DNA synthesis and is very active against cells in the late S and G2 phases of the cell cycle. Etoposide was reported to be used to serum starve Saos-2 M5(p53-/-) cells which were transfected by electroporation with indicated expression plasmids for flag-E2F1 and myc-EBNA3C for selection of colony forming units, thus studying the blocking effect of EBV Nuclear Antigen 3C on E2F1 Mediated Apoptosis Induced by the DNA Damage Response.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
Etoposide is used as a inhibits DNA synthesis and is very active against cells in the late S and G2 phases of the cell cycle. Etoposide was reported to be used to serum starve Saos-2 M5(p53-/-) cells which were transfected by electroporation with indicated expression plasmids for flag-E2F1 and myc-EBNA3C for selection of colony forming units, thus studying the blocking effect of EBV Nuclear Antigen 3C on E2F1 Mediated Apoptosis Induced by the DNA Damage Response.

Solubility
Insoluble in water.

Notes
Store solutions in DMSO at 4°C. For long term storage prepare aliquots and store at -20°C.
TRUSTED_SUSTAINABILITY

Identificadores de productos químicos

CAS 33419-42-0
Fórmula molecular C29H32O13
Peso molecular (g/mol) 588.56
Número MDL MFCD00869325,MFCD00869325
Clave InChI VJJPUSNTGOMMGY-MRVIYFEKSA-N
Sinónimo vjjpusntgommgy-nzlmilqcsa
PubChem CID 50936917
Nombre IUPAC (10R,11R,15R,16S)-16-{[(2R,4aR,6R,7R,8R,8aS)-7,8-dihydroxy-2-methyl-hexahydro-2H-pyrano[3,2-d][1,3]dioxin-6-yl]oxy}-10-(4-hydroxy-3,5-dimethoxyphenyl)-4,6,13-trioxatetracyclo[7.7.0.0³,⁷.0¹¹,¹⁵]hexadeca-1,3(7),8-trien-12-one
SMILES COC1=CC(=CC(OC)=C1O)[C@H]1[C@@H]2[C@H](COC2=O)[C@H](O[C@@H]2O[C@@H]3CO[C@@H](C)O[C@H]3[C@H](O)[C@H]2O)C2=CC3=C(OCO3)C=C12

Especificaciones

Nombre del producto químico o material Etoposide
Punto de fusión 236°C to 251°C
Color Blanco
Cantidad 25 mg
Índice Merck 14,3886
Información de solubilidad Insoluble in water.
Rotación óptica −107° (c=1 in Methanol/Dichloromethane 1:9)
Formula Weight (peso de la fórmula) 588.56
Forma física Powder

RUO – Research Use Only

Título del producto
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