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Tocris Bioscience™ EM 163

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10 mg
Descripción
EM 163 is a TIR-TIR interaction inhibitor, that is a TIR (Toll/ interleukin-1 receptor) domain peptidomimetic of MyD88 protein. EM 163 targets TIR domains in IL-1 receptors blocking the interaction with MyD88. EM 163 inhibits staphylococcal enterotoxin B (SEB)-induced inflammatory cytokine production in vivo. EM 163 protects mice from SEB shock-induced death. In rat hippocampal neurons in vitro, EM 163 blocks the activation of p38 and the inhibitory effects of IL-1β on protein synthesis triggered by chemically-induced long-term potentiation (LTP).
Especificaciones
Especificaciones
| Nombre del producto químico o material | 1-Methyl-2,5-bis[[[(1 S)-2-methyl-1-(1-pyrrolidinylcarbonyl)propyl](3-phenylpropyl)amino]carbonyl]pyridinium iodide |
| CAS | 1206480-93-4 |
| Cantidad | 10 mg |
| Objetivo | Cytokine Compounds |
| Fórmula molecular | C44H60IN5O4 |
| Pureza | 98% |
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