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Invitrogen™ EDAR Recombinant Mouse Monoclonal Antibody (EDAR12)

Código de producto. 30088186
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Cantidad:
200 μg
Tamaño de la unidad:
200 microgramos
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30088186 200 μg 200 microgramos
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Código de producto. 30088186 Proveedor Invitrogen™ N.º de proveedor MA551876

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Mouse Recombinant Monoclonal Antibody

EDAR12 recognises and binds to CRD1 of the extracellular domain of mouse EDAR. EDAR3 cross-reacts with EDAR derived from human, dog, rat and chicken when EDAR is fused to the glycosylphosphatidylinositol anchor of TRAILR3. EDAR is the receptor for the TNF family ligand EDA1, which is a type II transmembrane protein possessing a collagen-like domain and a C-terminal TNF-homology domain. EDAR is important for the correct development of skin appendages including hair, teeth and eccrine sweat glands. LoF mutations in the Eda gene is known to cause XLHED (X-linked hypohidrotic ectodermal dysplasia), and results in abnormal development.

This gene encodes a member of the tumor necrosis factor receptor family. The encoded transmembrane protein is a receptor for the soluble ligand ectodysplasin A, and can activate the nuclear factor-kappaB, JNK, and caspase-independent cell death pathways. It is required for the development of hair, teeth, and other ectodermal derivatives. Mutations in this gene result in autosomal dominant and recessive forms of hypohidrotic ectodermal dysplasia.
TRUSTED_SUSTAINABILITY

Especificaciones

Antígeno EDAR
Aplicaciones ELISA, Functional Assay, Western Blot, Immunocytochemistry, Surface Plasmon Resonance
Clasificación Recombinant Monoclonal
Clon EDAR12
Concentración 1 mg/mL
Conjugado Unconjugated
Formulación PBS with 0.02% ProClin 300
génica Edar
N.º de referencia del gen Q9R187, Q9UNE0
Alias de gen Anhidrotic ectodysplasin receptor 1; DL; Downless; downless homolog; downless, mouse, homolog of; ECTD10A; ECTD10B; ectodermal dysplasia receptor; ectodysplasin 1, anhidrotic receptor; ectodysplasin A receptor; ectodysplasin-A receptor; ED1R; ED3; ED5; EDA1R; EDA3; EDA-A1 receptor; EDA-A1R; Edar; HRM1; RGD1561714; Tumor necrosis factor receptor superfamily member EDAR
Símbolos de los genes Edar
Especie del huésped Mouse
Inmunógeno EDAR12 was prepared by immunixzing female OVE1B mice (with the Edar gene deleted) subcutaneously with mouse EDAR-Fc and positive hybridoma clones were screened for binding mEDAR by ELISA.
Método de purificación Protein A
Cantidad 200 μg
Estado normativo RUO
Primario o secundario Primary
ID de gen (Entrez) 10913, 13608, 365581, 428015, 481305
Especies diana Canine, Chicken, Human, Mouse, Rat
Contenido y almacenamiento Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Tipo de producto Antibody
Formulario Liquid
Isotype IgG1 κ
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