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Invitrogen™ Human DNA-PK Native Protein

Código de producto. 15378517
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Cantidad:
1 mg
Tamaño de la unidad:
cada uno
Código de producto. Cantidad unitSize
15378517 1 mg cada uno
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Código de producto. 15378517

Marca: Invitrogen™ PV5865

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Native Protein

For maximum recovery please spin prior to use. Unless noted below, aliquots of the 5 μg, 10 μg and 20 μg sizes of kinase are not recommended as materials can be used in original packaging until exhausted. For larger sizes, the number of freeze/thaws may be reduced by preparing aliquots, aliquots below 20 μL are not recommended. Please never store a kinase diluted. If properly stored at -80C, this product is guaranteed for 6 months from date of purchase. Native human protein purified from MOLT-4 cells. No special measures were taken to activate this kinase. Protein Form: Full Length

DNA-PK is a heterotrimeric, DNA-dependent protein kinase that initiates signaling cascades in response to DNA damage. DNA-PK is an atypical kinase, closely related to the PI3 kinases, and is often potently inhibited by small molecules designed to target PI3 kinases. DNA-PK encodes a component of the mediator complex, a transcriptional coactivator complex thought to be required for the expression of almost all genes. The mediator complex is recruited by transcriptional activators or nuclear receptors to induce gene expression, possibly by interacting with RNA polymerase II and promoting the formation of a transcriptional pre-initiation complex. Multiple transcript variants encoding different isoforms have been found for DNA-PK.
TRUSTED_SUSTAINABILITY

Especificaciones

Número de acceso P78527
Concentración Conc. Not Determined
Para utilizar con (aplicación) Kinase Assay
Formulación 25 mM HEPES with 0.2 mM EDTA, 10% glycerol, 10 mM MgCl2, 1 mM DTT, 50 mM KCl and no preservative; pH 7.5
ID de gen (Entrez) 5591
Peso molecular 600 kDa
Nombre Human DNA-Pk.
Cantidad 1 mg
Estado normativo RUO - research use only
Alias de gen AI326420; AU019811; DNA-dependent protein kinase catalytic subunit; DNAPDcs; DNAPK; DNA-Pk. catalytic subunit; DNA-PKcs; DNPK1; DOXNPH; doxorubicin nephropathy; dxnph; hyper-radiosensitivity of murine scid mutation, complementing 1; HYRC; HYRC1; I79_017613; IMD26; p350; p460; Prkdc; protein kinase, DNA activated, catalytic polypeptide; protein kinase, DNA-activated, catalytic polypeptide; scid; severe combined immunodeficiency; slip; Xrcc7
Nombre común DNA-Pk.
Familia Quinasa PIKK Kinase Family
Conjugado Unconjugated
Especie Human
Secuencia Full length
Contenido y almacenamiento -80°C, Avoid Freeze/Thaw Cycles
Formulario Liquid
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