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Cyclin B1 Monoclonal Antibody (GNS11), Invitrogen™

Código de producto. 11365033
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Cantidad:
500 μL
Tamaño de la unidad:
500 microlitros
Código de producto. Cantidad unitSize
11365033 500 μL 500 microlitros
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Código de producto. 11365033

Marca: Invitrogen MA514327

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Mouse Monoclonal Antibody

MA5-14327 targets Cyclin B1 in WB, ICC/IF, IHC (P), and IP applications and shows reactivity with Hamster, Human, mouse, and Rat samples. This antibody is not recommended for NIH-3T3 cells in Western blot applications. The MA5-14327 immunogen is human cyclin B1 protein. This antibody was orginally validated as part of a Thermo Scientific Cellomics High Content Screening Kit. The antibody sold separately may have slightly different performance and may need to be further optimized for the best results.

Cyclins bind to and regulate the activity of the Cyclin dependent protein kinases (CDKs). Cyclin B1 or CCNB1 is a regulatory protein involved in mitosis. It is essential for the control of the cell cycle at the G2/M transition. Cyclin B1 complexes with p34 (cdc2) to form the maturation-promoting factor (MPF). Two alternative transcripts have been found, a constitutively expressed transcript and a cell cycle-regulated transcript, that is expressed predominantly during G2/M phase. Cyclin B1 is not ubiquitinated during G2/M phase, resulting in its steady accumulation during G2 phase, followed by abrupt APC dependent destruction at the end of mitosis. Destruction of Cyclin B1 is required for cell cycle progression. Cyclin B1 is overexpressed in various cancers, including breast, prostate, and non-small cell lung cancer.
TRUSTED_SUSTAINABILITY

Especificaciones

Antígeno Cyclin B1
Aplicaciones Immunocytochemistry, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Clasificación Monoclonal
Clon GNS11
Concentración 0.2 mg/mL
Conjugado Unconjugated
Formulación PBS with 0.2% BSA and 0.09% sodium azide; pH 7.4
génica Ccnb1
N.º de referencia del gen P14635, P24860, P30277, Q08301
Alias de gen Ccn-2; CCNB; Ccnb1; Ccnb1-rs1; Ccnb1-rs13; Cycb; Cycb1; Cycb1-rs1; Cycb-4; Cycb-5; cyclin B; cyclin B1; cyclin B1, related sequence 1; cyclin B1, related sequence 13; G2/mitotic-specific cyclin B1; G2/mitotic-specific cyclin-B1; I79_013589; OTTHUMP00000221981; OTTHUMP00000223023
Símbolos de los genes Ccnb1
Especie del huésped Mouse
Inmunógeno Human cyclin B1 protein
Método de purificación Protein A
Cantidad 500 μL
Estado normativo RUO
Primario o secundario Primary
ID de gen (Entrez) 100770842, 25203, 268697, 891
Especies diana Hamster, Human, Mouse, Rat
Contenido y almacenamiento 4° C
Tipo de producto Antibody
Formulario Liquid
Isotype IgG2a
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