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Invitrogen™ Cyclin B1 Monoclonal Antibody (5G6)

Código de producto. 11315683
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Cantidad:
100 μL
Tamaño de la unidad:
100 microlitros
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11315683 100 μL 100 microlitros
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Código de producto. 11315683 Proveedor Invitrogen™ N.º de proveedor MA515714

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Descripción

Mouse Monoclonal Antibody

MA5-15714 targets CCNB1 in indirect ELISA, FACS, IF, and WB applications and shows reactivity with Human and Rat samples. The MA5-15714 immunogen is purified recombinant fragment of human CCNB1 expressed in E. Coli. MA5-15714 detects CCNB1 which has a predicted molecular weight of approximately 60kDa.

Cyclins bind to and regulate the activity of the Cyclin dependent protein kinases (CDKs). Cyclin B1 or CCNB1 is a regulatory protein involved in mitosis. It is essential for the control of the cell cycle at the G2/M transition. Cyclin B1 complexes with p34 (cdc2) to form the maturation-promoting factor (MPF). Two alternative transcripts have been found, a constitutively expressed transcript and a cell cycle-regulated transcript, that is expressed predominantly during G2/M phase. Cyclin B1 is not ubiquitinated during G2/M phase, resulting in its steady accumulation during G2 phase, followed by abrupt APC dependent destruction at the end of mitosis. Destruction of Cyclin B1 is required for cell cycle progression. Cyclin B1 is overexpressed in various cancers, including breast, prostate, and non-small cell lung cancer.
TRUSTED_SUSTAINABILITY

Especificaciones

Antígeno Cyclin B1
Aplicaciones ELISA, Flow Cytometry, Western Blot, Immunocytochemistry
Clasificación Monoclonal
Clon 5G6
Concentración Conc. Not Determined
Conjugado Unconjugated
Formulación Ascites with 0.03% sodium azide
génica Ccnb1
N.º de referencia del gen P14635, P30277
Alias de gen Ccn-2; CCNB; Ccnb1; Ccnb1-rs1; Ccnb1-rs13; Cycb; Cycb1; Cycb1-rs1; Cycb-4; Cycb-5; cyclin B; cyclin B1; cyclin B1, related sequence 1; cyclin B1, related sequence 13; G2/mitotic-specific cyclin B1; G2/mitotic-specific cyclin-B1; I79_013589; OTTHUMP00000221981; OTTHUMP00000223023
Símbolos de los genes Ccnb1
Especie del huésped Mouse
Inmunógeno Purified recombinant fragment of human CCNB1 expressed in E. Coli.
Cantidad 100 μL
Estado normativo RUO
Primario o secundario Primary
ID de gen (Entrez) 25203, 891
Especies diana Human, Rat
Contenido y almacenamiento Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Tipo de producto Antibody
Formulario Liquid
Isotype IgG1
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