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  5. Tocris BioScience™ CX-4945

Tocris BioScience™ CX-4945

Código de producto. 31900358
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10 mg
50 mg
Tamaño de la unidad:
10 miligramos
50 miligramos
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31900358 10 mg 10 miligramos
31900356 50 mg 50 miligramos
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Código de producto. 31900358 Proveedor Tocris BioScience™ N.º de proveedor 8993/10

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Descripción

Potent and selective CK2α and CK2α' inhibitor. Also blocks CK2-dependent HIF-1α transcription, causes cell-cycle arrest, induces apoptosis in cancer cells and induces stem cell reprogramming

CX-4945 (Silmitasertib) is a potent and selective inhibitor of protein kinase CK2α and CK2α' (IC50 = 1 nM). It shows greater than 500-fold selectivity for CK2 over a panel of > 200 kinases.

CX-4945 can be used, in combination with other small molecules, in fast chemical reprogramming protocols for the induction of human somatic cells and highly efficient generation of pluripotent stem cells (hCiPS) in a minimum of 16 days with robust repeatability and reliability.

CX-4945 has antiproliferative effects in vitro as it attenuates PI3K/Akt signalling, causes cell-cycle arrest and selectively induces apoptosis in cancer cells. In models of angiogenesis, CX-4945 inhibits human umbilical vein endothelial cell migration, tube formation, and blocks CK2-dependent hypoxia-induced factor 1 alpha (HIF-1α) transcription in cancer cells.

In vivo, CX-4945 displays robust antitumor activity with concomitant reduction of the mechanism-based biomarker phospho-p21 (T145) (murine xenograft model). CX-4945 is orally bioavailable.

TRUSTED_SUSTAINABILITY

Especificaciones

Nombre del producto químico o material Sodium 5-[(3-Chlorophenyl)amino]benzo[c]-2,6-naphthyridine-8-carboxylate
CAS 1309357-15-0
Cantidad 10 mg
Objetivo Casein Kinase 2 Inhibitors
Fórmula molecular C19H11ClN3O2Na
Pureza 98%
Título del producto
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