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Invitrogen™ CISD2 Polyclonal Antibody

Descripción
A suggested positive control is rat brain tissue lysate. PA5-34545 can be used with blocking peptide PEP-1588.
Defects in the CISD2 (CDGSH iron sulfur domain 2) gene are a cause of the neurodegenerative disorder Wolfram syndrome 2. CISD2 is a zinc finger protein that localizes to the endoplasmic reticulum and mitochondria and binds an iron/sulfur cluster. CISD2 interacts with Bcl-2 and can be displaced by the BH3-only protein BIK and contributes to the regulation of BIK-initiated autophagy. CISD2 deficiency in mice causes mitochondrial breakdown accompanied by autophagic cell death as well as the development of premature aging phenotype.
Especificaciones
Especificaciones
| Antígeno | CISD2 |
| Aplicaciones | Immunohistochemistry, Western Blot |
| Clasificación | Polyclonal |
| Concentración | 1 mg/mL |
| Conjugado | Unconjugated |
| Formulación | PBS with 0.02% sodium azide |
| génica | CISD2 |
| N.º de referencia del gen | Q8N5K1, Q9CQB5 |
| Alias de gen | 1500009M05Rik; 1500026J14Rik; 1500031D15Rik; AI848398; B630006A20Rik; BcDNA:RE49709; CDGSH iron sulfur domain 2; CDGSH iron sulfur domain-containing protein 2; CDGSH iron-sulfur domain-containing protein 2; CDGSH iron-sulfur domain-containing protein 2 homolog; Cdgsh2; CG1458; CG1458-PA; cisd2; Cisd2-PA; dkey-162b23.1; Dmel\CG1458; Dmel_CG1458; dWFS2; endoplasmic reticulum intermembrane small protein; ERIS; Miner1; MitoNEET; mitoNEET related 1; mitoNEET-related 1 protein; NAF-1; nervous system overexpressed protein 70; nervous system over-expressed protein 70; Noxp70; Nutrient-deprivation autophagy factor-1; RE49709p; RGD1566242; RH38554p; WFS2; Zcd2; zgc:64148; zgc:64148 protein; zinc finger, CDGSH-type domain 2; zKM0001 |
| Símbolos de los genes | CISD2 |
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Título del producto
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