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Descripción
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 μg/mL. Positive Control - WB: human A375 whole cell. Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
CD72 is a transmembrane glycoprotein expressed as a homodimer especially in B cells, but also in other antigen presenting cells such as dendritic cells and macrophages. Through one of its immunoreceptor tyrosine-based inhibitory motives (ITIMs), CD72 interacts with tyrosine phosphatase SHP-1, thereby suppressing B cell responsiveness. Binding of CD72 with its ligand CD100 (Sema4D) prevents BCR association and phosphorylation of CD72 and results in dissociation of SHP-1 from CD72, thus enables B cell activation.
Especificaciones
Especificaciones
| Antígeno | CD72 |
| Aplicaciones | ELISA, Western Blot |
| Clasificación | Polyclonal |
| Concentración | 500 μg/mL |
| Conjugado | Unconjugated |
| Formulación | PBS with 4mg trehalose and 0.05mg sodium azide |
| génica | CD72 |
| N.º de referencia del gen | P21854 |
| Alias de gen | B-cell differentiation antigen CD72; CD72; CD72 antigen; Cd72 molecule; CD72b; CD72c; Ly-19; Ly32; Ly-32; LYB2; Lyb-2; Ly-m19; lymphocyte antigen 32; RP11-331F9.9 |
| Símbolos de los genes | CD72 |
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Título del producto
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