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CD209 Mouse anti-Human, FITC, Clone: DCN46, BD

Mouse Monoclonal Antibody

182.00€ - 635.00€

Especificaciones

Antígeno CD209
Clon DCN46
Aplicaciones Flow Cytometry
Clasificación Monoclonal
Conjugado FITC
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Productos 2
Código de producto Marca Cantidad Precio Cantidad y disponibilidad  
Código de producto Marca Cantidad Precio Cantidad y disponibilidad  
15891309
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BD Biosciences
561764
25 Tests
182.00€
cada uno
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Fecha estimada de envío: 23-04-2024
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15896588
Ver documentos Detalles de la promoción
BD Biosciences
551264
100 Tests
635.00€
cada uno
Ver productos alternativos
Ahorre hasta 
»
Fecha estimada de envío: 23-04-2024
para ver el stock
Por favor, para comprar este producto. ¿No tiene usuario web? Regístrese hoy mismo.
Descripción

Descripción

The DCN46 antibody specifically binds to dendritic cell-specific ICAM-3 grabbing nonintegrin (DC-SIGN or CD209), a type-II membrane protein of approximately 44 kDa with a mannose-binding C-type lectin domain. It is highly expressed on dendritic cells in mucosal tissues. Its sequence is identical to the HIV-1 envelope gp120-binding C-type lectin, and reports suggest that DC-SIGN binds to HIV-1 gp120 and effectively transmits infectious HIV-1 to resting T lymphocytes expressing CD4 and chemokine receptors. The C-type lectin domain of DC-SIGN is also capable of binding other pathogenic viruses, bacteria, and parasites. Reports also suggest that DC-SIGN enables the highly efficient migration of dendritic cells from blood into the tissues. It can interact with ICAM-2, which has a similar sequence as ICAM-3, and is abundantly expressed on vascular and lymphoid endothelium. Thus, DC-SIGN mediates dendritic cells rolling and transendothelial migration, and its interaction with ICAM-2 is essential to specific migratory functions of dendritic cells.

This antibody is routinely tested by flow cytometric analysis. Other applications were tested at BD Biosciences Pharmingen during antibody development only or reported in the literature.

Especificaciones

Especificaciones

CD209
Flow Cytometry
FITC
RUO
Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
IgG2b κ
Affinity Purified
DC-SIGN
DCN46
Monoclonal
Mouse
Human
Human Monocyte Derived DC Cells
Primary
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
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For Research Use Only.