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Invitrogen™ CD137 (4-1BB) Monoclonal Antibody (4B4-1)
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Código de producto. 16342824
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Cantidad:
100 μg
Tamaño de la unidad:
100 microgramos
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16342824 100 μg 100 microgramos
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Código de producto. 16342824 Proveedor Invitrogen™ N.º de proveedor MA528560

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Description

Mouse Monoclonal Antibody

This antibody recognizes an extracellular conformational epitope on CD137, an approximately 40 kDa type I transmembrane protein of the TNFR family expressed mainly on activated T cells.

CD137, also known as TNFRSF9 or 4-1BB, is an inducible costimulatory molecule expressed mainly on activated T cells. Its ligand, known as 4-1BBL, is expressed on activated macrophages, mature B cells, hematopoietic stem cells, and myeloid progenitor cells. CD137 signaling leads to maintaining the survival of activated T cells and CD8+ memory T cells, and clonal expansion of T cells, but also to suppressing myelopoiesis and dendritic cell development. Triggered CD137 induces a cytokine release profile regulating peripheral monocyte survival. Soluble forms of CD137 may provide negative control mechanism for some immune responses.
TRUSTED_SUSTAINABILITY

Specifications

Antígeno CD137 (4-1BB)
Aplicaciones ELISA, Flow Cytometry, Immunoprecipitation
Clasificación Monoclonal
Clon 4B4-1
Concentración 1 mg/mL
Conjugado Unconjugated
Formulación PBS with 15mM sodium azide; pH 7.4
génica TNFRSF9
N.º de referencia del gen Q07011
Alias de gen 4 1 BB; 41BB; 4-1BB; 4-1BB ligand receptor; A930040I11Rik; AA408498; AI325004; Cd137; CD137 antigen; CDw137; EGK_00183; homolog of mouse 4-1BB; ILA; induced by lymphocyte activation (ILA); interleukin-activated receptor, homolog of mouse Ly63; Ly63; receptor protein 4-1BB; s4 1 BB; s4 1BB; s41BB; sCD137; secreted CD137 antigen; soluble 4 1 BB; soluble 4 1BB; soluble 41BB; soluble CD137; T cell antigen ILA; T-cell antigen 4-1BB; T-cell antigen 4-1BB homolog; T-cell antigen ILA; TNF receptor superfamily member 9; TNFRSF9; Tumor necrosis factor receptor superfamily member 9; tumor necrosis factor receptor superfamily, member 9
Símbolos de los genes TNFRSF9
Especie del huésped Mouse
Inmunógeno Recombinant human CD137 ectodomain.
Método de purificación Protein A
Cantidad 100 μg
Estado normativo RUO
Primario o secundario Primary
ID de gen (Entrez) 100196937, 102127961, 3604, 708281, 746029
Especies diana Human, Monkey, Baboon, Rhesus Macaque, Chimpanzee, Cynomolgus Monkey
Contenido y almacenamiento 4°C, do not freeze
Tipo de producto Antibody
Formulario Liquid
Isotype IgG1 κ
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