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  6. CD103 (Integrin alpha E) Monoclonal Antibody (B-Ly7), NovaFluor™ Blue 660-120S, eBioscience™, Invitrogen™

CD103 (Integrin alpha E) Monoclonal Antibody (B-Ly7), NovaFluor™ Blue 660-120S, eBioscience™, Invitrogen™

Código de producto. p-7250756
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Cantidad:
100 Tests
25 Tests
Tamaño de la unidad:
paquete de 100
paquete de 25
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17882914 25 Tests paquete de 25
17882954 100 Tests paquete de 100
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Código de producto. 17882914 Proveedor Invitrogen N.º de proveedor H075T02B08

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Descripción

Mouse Monoclonal Antibody

The B-Ly7 monoclonal antibody reacts with human CD103, the alpha E integrin. CD103 non-covalently associates with integrin beta 7. CD103 is expressed mainly on intraepithelial lymphocytes and a small subset of peripheral lymphocytes. CD103 is also expressed by hairy cell leukemia (HCL) and by some chronic B cell lymphocytic leukemias. In vitro stimulation of human T cells with mitogens induces upregulation of CD103. Epithelial cell antigen, E-cadherin, binds to CD103 and mediates homing of lymphocytes to the intestinal epithelium. Applications Reported: B-Ly7 has been reported for use in flow cytometric analysis. Applications Tested: This B-Ly7 antibody has been pre-titrated and tested by flow cytometric analysis of 2-3 day PHA-activated human peripheral blood cells. This can be used at 5 uL (0.6 ug) per test. A test is defined as the amount (ug) of antibody that will stain a cell sample in a final volume of 100 uL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. NovaFluor dyes are not compatible with DNA intercalating viability dyes. Invitrogen LIVE/DEAD Fixable Dead Cell stains are recommended for use with NovaFluor dyes. Use 5uL of CellBlox Blocking Buffer per stained cell sample containing 10^3 to 10^8 cells. Excitation: 509 nm; Emission: 665 nm; Laser: 488 nm (Blue) Laser

CD103 (ITGAE, Integrin alpha E) is molecule that is expressed on mucosa-associated T lymphocytes and activated cells and on subet of TGF beta -1 cells. In particular, CD103 includes a 150kDa alpha chain and a 120kDa beta chain. CD103 is expressed by 0.5 to 2% of resting lymphocytes in peripheral blood and lymphoid organs. CD103 antibody stains a few bone marrow cells and, rarely, peripheral blood lymphocytes. CD103 is part of the integrin family which are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. ITGAE encodes an I-domain-containing alpha integrin that undergoes post-translational cleavage in the extracellular domain, yielding disulfide-linked heavy and light chains. In combination with the beta 7 integrin, CD103 protein forms the E-cadherin binding integrin known as the human mucosal lymphocyte-1 antigen. CD103 is preferentially expressed in human intestinal intraepithelial lymphocytes (IEL), and in addition to a role in adhesion, it may serve as an accessory molecule for IEL activation. Diseases associated with CD103 dysfunction include hairy cell leukemia and splenic marginal zone lymphoma.
TRUSTED_SUSTAINABILITY

Especificaciones

Antígeno CD103 (Integrin alpha E)
Aplicaciones Flow Cytometry
Clasificación Monoclonal
Clon B-Ly7
Concentración 0.6 μg/Test
Conjugado NovaFluor Blue 660-120S
Formulación PBS with 0.09% sodium azide; pH 7.2
génica Itgae
N.º de referencia del gen P38570
Alias de gen A530055J10; alpha-E1; alpha-M290; aM290; antigen CD103; antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide; CD103; DC; DCs; HML-1 antigen; human mucosal lymphocyte antigen 1, alpha polypeptide; HUMINAE; integrin alpha E; integrin alpha E, epithelial-associated; integrin alpha E1, epithelial-associated; integrin alpha M290; Integrin alpha-E; Integrin alpha-E heavy chain; Integrin alpha-E light chain; Integrin alpha-IEL; integrin subunit alpha E; integrin, alpha E; integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide); integrin, alpha E, epithelial-associated; Intregrin alpha E2; Itgae; MGC141996; Mucosal lymphocyte 1 antigen
Símbolos de los genes Itgae
Especie del huésped Mouse
Método de purificación Affinity chromatography
Cantidad 25 Tests
Estado normativo RUO
Primario o secundario Primary
ID de gen (Entrez) 3682
Especies diana Human
Contenido y almacenamiento 4° C, store in dark, DO NOT FREEZE!
Formulario Liquid
Isotype IgG1 κ
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