missing translation for 'onlineSavingsMsg'
Learn More
  1. Home
  2. Products
  3. Reactivos para análisis de proteínas
  4. Moléculas pequeñas bioactivas
  5. Tocris Bioscience™ Carfilzomib

Tocris Bioscience™ Carfilzomib
GREENER_CHOICE

Código de producto. 18737066
Cambiar vista
Click to view available options
Cantidad:
10 mg
50 mg
Tamaño de la unidad:
10 miligramos
50 miligramos
2 product options available for selection
Product selection table with 2 available options. Use arrow keys to navigate and Enter or Space to select.
Código de producto. Cantidad unitSize
18737066 50 mg 50 miligramos
18726356 10 mg 10 miligramos
Use arrow keys to navigate between rows. Press Enter or Space to select a product option. 2 options available.
2 options
Este artículo no se puede devolver. Vea la política de devoluciones
Código de producto. 18737066 Proveedor Tocris Bioscience™ N.º de proveedor 7188/50

Please to purchase this item. Need a web account? Register with us today!

Este artículo no se puede devolver. Vea la política de devoluciones

Description

Potent irreversible proteasome inhibitor; active in vivo

Carfilzomib is a potent irreversible proteasome inhibitor. Preferentially inhibits the chymotrypsin-like β5 subunit of the constitutive 20S proteasome (IC50 = 5.2 nM) and the β5i subunit of the immunoproteasome 20Si (LMP7; IC50 = 14 nM) in vitro with minimal cross-reactivity to other proteases. Exhibits little or no effect on PGPH and T-L activities. Activates prosurvival autophagy and induces cell apoptosis. Acts synergistically with dexamethasone (Cat. No. 1126). Suppresses tumor growth in an in vivo xenograft model. Decreases bone resorption and enhances bone formation in non-tumor bearing mice.
TRUSTED_SUSTAINABILITY

Specifications

Nombre del producto químico o material (αS)-α-[[2-(4-Morpholinyl)acetyl]amino]benzenebutanoyl-L-leucyl-N-[(1 S)-3-methyl-1-[[(2 R)-2-methyl-2-oxiranyl]carbonyl]butyl]-L-phenylalaninamide
CAS 868540-17-4
Cantidad 50 mg
Objetivo Proteasome Inhibitors
Fórmula molecular C40H57N5O7
Pureza 0.98
Product Title
Select an issue

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.