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Invitrogen™ Bcl-xL Recombinant Rabbit Monoclonal Antibody (036)
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Código de producto. 17148935
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Cantidad:
100 μL
Tamaño de la unidad:
100 microlitros
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Código de producto. Cantidad unitSize
17148935 100 μL 100 microlitros
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Código de producto. 17148935 Proveedor Invitrogen™ N.º de proveedor MA529655

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Descripción

Rabbit Recombinant Monoclonal Antibody

This product is preservative free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%-0.1%). Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire. This antibody has specificity for Mouse BCL2L1/Bcl-XL.

BCL-XL is a part of the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. BCL-XL is located at the outer mitochondrial membrane, and have been shown to regulate outer mitochondrial membrane channel (VDAC) opening. VDAC regulates mitochondrial membrane potential and controls the production of reactive oxygen species and release of cytochrome C by mitochondria, both of which are the potent inducers of cell apoptosis. Two alternatively spliced transcript variants, which encode distinct isoforms, have been reported. The longer isoform acts as an apoptotic inhibitor and the shorter form acts as an apoptotic activator.
TRUSTED_SUSTAINABILITY

Especificaciones

Antígeno Bcl-xL
Aplicaciones Immunoprecipitation, Western Blot
Clasificación Recombinant Monoclonal
Clon 036
Concentración 1 mg/mL
Conjugado Unconjugated
Formulación PBS with no preservative
génica BCL2L1
N.º de referencia del gen Q64373
Alias de gen anti-apoptosis regulatory protein; apoptosis regulator Bcl-X; B cell lymphoma 2 like; B cell lymphoma like X; B-cell leukemia/lymphoma x; Bcl(X)L; BCL2 like 1; Bcl2l; BCL2L1; bcl2-L-1; BCL2-like 1; Bcl-2-like protein 1; BCLX; bcl-x; BCLXL; Bcl-XL; BCL-XL/S; BCLXS; bcl-xS; Blc2l; DKFZp781P2092; EGK_02534; OTTHUMP00000030550; OTTHUMP00000030552; OTTHUMP00000030555; OTTHUMP00000030556; OTTHUMP00000030557; PPP1R52; protein phosphatase 1, regulatory subunit 52; RP5-857M17.3
Símbolos de los genes BCL2L1
Especie del huésped Rabbit
Inmunógeno Recombinant Mouse BCL2L1/Bcl-XL Protein (Met1-Arg212).
Método de purificación Protein A
Cantidad 100 μL
Estado normativo RUO
Primario o secundario Primary
ID de gen (Entrez) 12048
Especies diana Mouse
Contenido y almacenamiento Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Tipo de producto Antibody
Formulario Liquid
Isotype IgG
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