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Invitrogen™ BAX Polyclonal Antibody
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Código de producto. 17721784
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Cantidad:
100 μL
Tamaño de la unidad:
100 microlitros
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17721784 100 μL 100 microlitros
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Código de producto. 17721784 Proveedor Invitrogen™ N.º de proveedor PA5120382

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Descripción

Rabbit Polyclonal Antibody

Positive test controls include: 293T, HT-1080, Raji, HeLa, Mouse lung, Mouse testis, Rat testis, Rat ovary. The target is usually found in the following locations: Cytoplasm, Cytoplasm, Mitochondrion membrane, Single-pass membrane protein. Immunogen sequence: MDGSGEQPRG GGPTSSEQIM KTGALLLQGF IQDRAGRMGG EAPELALDPV PQDASTKKLS ECLKRIGDEL DSNMELQRMI AAVDTDSPRE VFFRVAADMF.

BAX is a members of the Bcl-2 Family and plays an important role in regulation of apoptosis. Whereas Bcl-2 is commonly regarded as an anti-apoptotic protein, BAX is considered to have a pro-apoptotic function. Regulation of apoptosis is supposed to involve both homo- and heterodimerization of different isoforms of BAX and Bcl-2. The Bax gene encodes different isoforms including Bax alpha (21 kDa) and Bax beta (24 kDa), whereas both isoforms contain the BH1, BH2 and BH3 domains, Bax beta has a unique carboxyl terminus and does not contain a hydrophobic transmembrane domain. Bcl-2 is also expressed in different Isoforms. Bcl-2 beta differs in the 3' UTR and coding region compared to variant alpha. Bcl-2 beta is shorter (22 kDa) and has a distinct C-terminus compared to Bcl-2 alpha (26 kDa). BAX is a member of the BCL-2 family of proteins, which function as regulators of apoptosis. Overexpression of BAX functions to promote cell death. BAX can form homodimers and is also able to heterodimerize with other BCL-2 related proteins.
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Especificaciones

Antígeno BAX
Aplicaciones ELISA, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot, Immunocytochemistry
Clasificación Polyclonal
Concentración 2.68 mg/mL
Conjugado Unconjugated
Formulación PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
génica BAX
N.º de referencia del gen Q07812, Q07813, Q63690
Alias de gen apoptosis regulator BAX; Apoptosis regulator Bcl-X; Bax; Bax zeta; BAX-ALPHA; Bax-alpha protein; Baxdelta2G9; Baxdelta2G9omega; Baxdelta2omega; BCL2 associated X protein; BCL2 associated X, apoptosis regulator; BCL2 like 1; BCL2-associated protein; Bcl-2-associated protein Bax; Bcl2-associated protein Bax; Bcl-2-associated X protein; BCL2-associated X protein; BCL2-associated X protein omega; BCL2L; BCL2L1; Bcl2-L-1; BCL2L4; Bcl2-L-4; BCL2-like 1; bcl-2-like protein 1; Bcl-2-like protein 4; BCLX; Bcl-X; BCL-XL/S; PPP1R52; protein phosphatase 1, regulatory subunit 52
Símbolos de los genes BAX
Especie del huésped Rabbit
Inmunógeno Recombinant fusion protein containing a sequence corresponding to amino acids 1-100 of human Bax (NP_620116.1).
Método de purificación Affinity Chromatography
Cantidad 100 μL
Estado normativo RUO
Primario o secundario Primary
ID de gen (Entrez) 12028, 24887, 581
Especies diana Human, Mouse, Rat
Contenido y almacenamiento -20°C, Avoid Freeze/Thaw Cycles
Tipo de producto Antibody
Formulario Liquid
Isotype IgG
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