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  5. Tocris Bioscience™ AZD 1208

Tocris Bioscience™ AZD 1208
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Código de producto. 18775466
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Cantidad:
10 mg
50 mg
Tamaño de la unidad:
10 miligramos
50 miligramos
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18775466 50 mg 50 miligramos
18747896 10 mg 10 miligramos
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Código de producto. 18775466 Proveedor Tocris Bioscience™ N.º de proveedor 6310/50

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Descripción

Potent pan Pim kinase inhibitor

AZD 1208 is a potent pan Pim kinase inhibitor (IC50 values are 0.4, 1.9 and 5.0 nM for Pim-1, 3 and 2, respectively). Exhibits >43-fold higher affinity for Pim kinases over a range of other kinases. Induces cell cycle arrest and apoptosis in AML cell lines in vitro and inhibits growth of tumor xenografts in vivo. AZD 1208 downmodulates the expression of Mayaro virus (MAYV) structural protein E1 and non-structural protein 1 (nsP1), and it reduces MAYV replication in a dose-dependent manner in HeLa or HDFs cells. Chemosensitizer.
TRUSTED_SUSTAINABILITY

Especificaciones

Nombre del producto químico o material (5Z)-5-[[2-[(3R)-3-Amino-1-piperidinyl][1,1'-biphenyl]-3-yl]methylene]-2,4-thiazolidinedione
CAS 1204144-28-4
Intervalo de porcentaje de ensayo >98%
Cantidad 50 mg
Fórmula molecular C21H21N3O2S
Formula Weight (peso de la fórmula) Observed MW: 379.48
Título del producto
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