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  5. Tocris Bioscience™ AS 1842856

Tocris Bioscience™ AS 1842856
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Código de producto. 18756916
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Cantidad:
10 mg
50 mg
Tamaño de la unidad:
10 miligramos
50 miligramos
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18756916 50 mg 50 miligramos
18715816 10 mg 10 miligramos
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Código de producto. 18756916 Proveedor Tocris Bioscience™ N.º de proveedor 4265/50

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Descripción

Potent and selective Foxo1 inhibitor; orally bioavailable

AS 1842856 is a potent and selective Foxo1 inhibitor (IC50 values are 33 nM at Foxo1 and >1 μM at Foxo3a and Foxo4); decreases Foxo-mediated promoter activity by 70%, 20% and 3% at Foxo1, Foxo4 and Foxo3, respectively. Regulates gluconeogenesis both in vitro and in vivo. Attenuates fasting plasma glucose level in diabetic db/db mice. Also suppresses autophagy, adipocyte differentiation and soluble guanylyl cyclase expression. Also inhibits STAT3 signaling in NSCLC. Orally bioavailable.
TRUSTED_SUSTAINABILITY

Specifications

Nombre del producto químico o material 5-Amino-7-(cyclohexylamino)-1-ethyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid
CAS 836620-48-5
Cantidad 50 mg
Fórmula molecular C18H22FN3O3
Pureza 98%
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