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PeproTech ApoE3 Polyclonal Antibody, PeproTech®, Invitrogen™

Código de producto. 17825683
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Cantidad:
1 mg
100 μg
50 μg
Tamaño de la unidad:
1 miligramo
100 microgramos
50 microgramos
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17825683 50 μg 50 microgramos
17864933 100 μg 100 microgramos
17805673 1 mg 1 miligramo
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Código de producto. 17825683 Proveedor PeproTech N.º de proveedor 500P23850UG

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Descripción

Rabbit Polyclonal Antibody

AA Sequence of recombinant protein: MKVEQAVETE PEPELRQQTE WQSGQRWELA LGRFWDYLRW VQTLSEQVQE ELLSSQVTQE LRALMDETMK ELKAYKSELE EQLTPVAEET RARLSKELQA AQARLGADME DVCGRLVQYR GEVQAMLGQS TEELRVRLAS HLRKLRKRLL RDADDLQKRL AVYQAGAREG AERGLSAIRE RLGPLVEQGR VRAATVGSLA GQPLQERAQA WGERLRARME EMGSRTRDRL DEVKEQVAEV RAKLEEQAQQ IRLQAEAFQA RLKSWFEPLV EDMQRQWAGL VEKVQAAVGT SAAPVPSDNH. Preparation: Produced from sera of rabbits immunized with highly pure Recombinant Huma ApoE3. Anti-Human ApoE3-specific antibody was purified by affinity chromatography employing an immobilized Human ApoE3 matrix. Sandwich ELISA: To detect Human ApoE3 by sandwich ELISA (using 100 μL/well antibody solution) a concentration of 0.5-2.0 μg/mL of this antibody is required. This antigen affinity purified antibody, in conjunction with PeproTech Biotinylated Anti-Human ApoE3 (500-P238Bt) as a detection antibody, allows the detection of at least 0.2-0.4 ng/well of Recombinant Human ApoE3. Western Blot: To detect Human ApoE3 by Western Blot analysis this antibody can be used at a concentration of 0.1-0.2 μg/mL. Used in conjunction with compatible secondary reagents the detection limit for Recombinant Human ApoE3 is 1.5-3.0 ng/lane, under either reducing or non-reducing conditions.

ApoE belongs to a group of proteins that bind reversibly with lipoprotein and play an important role in lipid metabolism. In addition to facilitating solubilization of lipids, these proteins help to maintain the structural integrity of lipoproteins, serve as ligands for lipoprotein receptors, and regulate the activity of enzymes involved in lipid metabolism. Significant quantities of ApoE are produced in the liver and brain, and to some extent in almost every organ. ApoE is an important constituent of all plasma lipoproteins. Its interaction with specific ApoE receptor enables uptake of chylomicron remnants by liver cells, which is an essential step during normal lipid metabolism. It also binds with the LDL receptor (apo B/E). Defects in ApoE are a cause of hyperlipoproteinemia type III. ApoE exists in three major isoforms; E2, E3, and E4, which differ from one another by a single amino-acid substitution. E3 is the most common isoform and is present in 40-90% of the population.
TRUSTED_SUSTAINABILITY

Especificaciones

Antígeno ApoE3
Aplicaciones ELISA, Western Blot
Clasificación Polyclonal
Concentración 0.1-1.0 mg/mL
Conjugado Unconjugated
Formulación PBS with no preservative
génica APOE
N.º de referencia del gen P02649
Alias de gen ApoE
Símbolos de los genes APOE
Especie del huésped Rabbit
Inmunógeno E.coli-derived Recombinant Human ApoE3.
Método de purificación Antigen affinity chromatography
Cantidad 50 μg
Estado normativo RUO
Primario o secundario Primary
ID de gen (Entrez) 348
Especies diana Human
Contenido y almacenamiento -20°C
Tipo de producto Antibody
Formulario Lyophilized
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