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vav 1 guanine nucleotide exchange factor, Mouse, Clone: 1A6, Abnova™
Mouse monoclonal antibody raised against a partial recombinant VAV1.
Marca: Abnova H00007409-M02.100ug
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Descripción
The protein encoded by this proto-oncogene is a member of the Dbl family of guanine nucleotide exchange factors (GEF) for the Rho family of GTP binding proteins. The protein is important in hematopoiesis, playing a role in T-cell and B-cell development and activation. This particular GEF has been identified as the specific binding partner of Nef proteins from HIV-1. Coexpression and binding of these partners initiates profound morphological changes, cytoskeletal rearrangements and the JNK/SAPK signaling cascade, leading to increased levels of viral transcription and replication. [provided by RefSeq
Sequence: RGLTELVEFYQQNSLKDCFKSLDTTLQFPFKEPEKRTISRPAVGSTKYFGTAKARYDFCARDRSELSLKEGDIIKILNKKGQQGWWRGEIYGRVGWFPANYVEEDYSEYCEspecificaciones
| vav 1 guanine nucleotide exchange factor | |
| Monoclonal | |
| Unconjugated | |
| PBS with no preservative; pH 7.4 | |
| BC013361 | |
| VAV1 | |
| VAV1 (AAH13361, 681 a.a. ∼ 790 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. | |
| 100 μg | |
| Signal Transduction | |
| Primary | |
| Human | |
| Antibody |
| ELISA, Western Blot | |
| 1A6 | |
| Mouse monoclonal antibody raised against a partial recombinant VAV1. | |
| VAV1 | |
| VAV | |
| Mouse | |
| Affinity Purified | |
| RUO | |
| Yes | |
| 7409 | |
| Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. | |
| IgG2a κ |
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