anti-NQO1, Polyclonal, Thermo Scientific™

Descripción

NQO1 Polyclonal antibody PA5-19624 from Thermo Scientific™ specifically detects NQO1 in Guinea Pig, Human, Mouse and Rat samples. It is validated for ELISA, Immunocytochemistry, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin) and Western Blot.

This gene is a member of the NADfamily and encodes a cytoplasmic 2-electron reductase. This FAD-binding protein forms homodimers and reduces quinones to hydroquinones. This protein's enzymatic activity prevents the one electron reduction of quinones that results in the production of radical species. Mutations in this gene have been associated with tardive dyskinesia, an increased risk of hematotoxicity after exposure to benzene, and susceptibility to various forms of cancer. Altered expression of this protein has been seen in many tumors and is also associated with Alzheimer's disease . Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
Host Species: Rabbit
Cross Reactivity: Guinea Pig, Human, Mouse, Rat
Isotype: IgG
Immunogen: Synthetic peptide conjugated to KLH derived from within residues 200 to the C-terminus of Human NQO1.
Formulation: 100μg Purified Antibody (1mg/ml) in PBS, with 1% BSA and 0.02% sodium azide; pH7.4
Synonyms: DHQU, DIA4, DTD, NMOR1, NMORI, QR1, DT-diaphorase; NAD(P)H dehydrogenase [quinone] 1; NAD(P)H:Quinone acceptor oxidoreductase type 1; NAD(P)H:menadione oxidoreductase 1; NAD(P)H:quinone oxidoreductase 1; NAD(P)H:quinone oxireductase; azoreductase; diaphorase (NADH/NADPH) (cytochrome b-5 reductase); diaphorase-4; dioxin-inducible 1; menadione reductase; phylloquinone reductase; quinone reductase 1
Uniprot Accession: P05982, P15559, Q64669, Q8CHK7
Entrez GeneID: 100135582, 1728, 18104, 24314
Gene Symbol: NQO1
Heat mediated antigen retrieval recommended prior to tissue staining.