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CD274 Mouse anti-Human, APC, Clone: MIH1, BD
Descripción
The MIH1 monoclonal antibody specifically binds to CD274, also known as Programmed Death Ligand 1 (PD-L1) and B7 Homolog 1 (B7-H1). CD274/PD-L1 and CD273/PD-L2 are members of the B7 family within the Immunoglobulin superfamily. These type I transmembrane glycoproteins function as ligands for CD279, likewise known as the Programmed Death 1 (PD-1) receptor. CD274 is expressed on activated dendritic cells, macrophages and T cells. Studies show some overlapping functions of CD274 and CD273 and indicate an important role for CD279 and its ligands in regulating T and B cell responses. CD274 is also expressed on placental trophoblasts, myocardial endothelium, cortical thymic epithelial cells, keratinocytes, and carcinomas. The MIH1 antibody is reportedly a blocking antibody.
Especificaciones
Especificaciones
| Antígeno | CD274 |
| Aplicaciones | Flow Cytometry |
| Clasificación | Monoclonal |
| Clon | MIH1 |
| Conjugado | APC |
| Descripción | B7-H1; Programmed death ligand 1; PD-L1; PDCD1 ligand 1; PDCD1L1; PDCD1LG1 |
| Formulación | Aqueous buffered solution containing BSA and ≤0.09% sodium azide. |
| Especie del huésped | Mouse |
| Inmunógeno | Human B7-H1 Transfected Cell Line |
| Método de purificación | Affinity Purified |
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