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Amiloride hydrochloride dihydrate

Código de producto. 15424599
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5 g
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Código de producto. 15424599 Proveedor Thermo Scientific Alfa Aesar N.º de proveedor J62168.06
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Descripción

Sodium channel blocker | CAS: 17440-83-4 | C6H13Cl2N7O3 | 302.116 g/mol

Amiloride hydrochloride dihydrate is used as a calcium channel and sodium channel protein inhibitor. It reduces electrical potential across tubular epithelium, inhibits angiogenesis and inhibits capillary morphogenesis completely and reversibly at approximately 130 ?M. Amiloride

  • HCl is an inhibitor of Sodium/Potassium-ATPase Protein. Defines the I2A-amiloride sensitive and I2B-amiloride insensitive imidazoline binding Blocks TRPP3, acid sensing- (ASIC) and mechanogated membrane-ion channels, as well as the Na+/H+ exchanger. Also inhibits urokinase-type plasminogen activator (uPA); has no effect on tissue-type plasminogen activator.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
Amiloride hydrochloride dihydrate is used as a calcium channel and sodium channel protein inhibitor. It reduces electrical potential across tubular epithelium, inhibits angiogenesis and inhibits capillary morphogenesis completely and reversibly at approximately 130 μM. Amiloride • HCl is an inhibitor of Sodium/Potassium-ATPase Protein. Defines the I2A-amiloride sensitive and I2B-amiloride insensitive imidazoline binding Blocks TRPP3, acid sensing- (ASIC) and mechanogated membrane-ion channels, as well as the Na+/H+ exchanger. Also inhibits urokinase-type plasminogen activator (uPA); has no effect on tissue-type plasminogen activator.

Solubility
Soluble in water at 50mg/ml

Notes
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Keep away from strong oxidizing agents.
TRUSTED_SUSTAINABILITY

Identificadores de productos químicos

CAS 17440-83-4
Fórmula molecular C6H13Cl2N7O3
Peso molecular (g/mol) 302.116
Número MDL MFCD00058197
Clave InChI LTKVFMLMEYCWMK-UHFFFAOYSA-N
Sinónimo amiloride hydrochloride dihydrate, modamide, nirulid, amiloride hcl, amiloride hcl dihydrate, amilorid hydrochlorid-2-wasser, unii-fzj37245uc, amiloride hydrochloride usan:usp, amiloride dihydrate hydrochloride, n-amidino-3,5-diamino-6-chloropyrazinecarboxamide hydrochloride dihydrate
PubChem CID 68540
ChEBI CHEBI:2640
Nombre IUPAC 3,5-diamino-6-chloro-N-(diaminomethylidene)pyrazine-2-carboxamide;dihydrate;hydrochloride
SMILES C1(=C(N=C(C(=N1)Cl)N)N)C(=O)N=C(N)N.O.O.Cl

Especificaciones

Nombre del producto químico o material Amiloride hydrochloride dihydrate
Punto de fusión >240°C
Color Yellow
Cantidad 5 g
Número UN UN2811
Índice Merck 14,406
Información de solubilidad Soluble in water at 50mg/ml
Formula Weight (peso de la fórmula) 266.09
Forma física Powder

RUO – Research Use Only

Título del producto
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