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Invitrogen™ ADAP Polyclonal Antibody

Descripción
A suggested positive control is K562 cell lysate. PA5-20401 can be used with blocking peptide PEP-0518.
The adhesion and degranulation adaptor protein (ADAP) was initially identified as a molecular adapter that couples T cell receptor (TCR) stimulation to the avidity of integrins governing T cell adhesion. TCR stimulation promotes the formation of a multi-protein complex containing CARMA1, MALT1, and BCL-10, which through the association of ADAP, ultimately activates the NF-kappa-B family of transcription factors. More recent experiments have shown that ADAP controls optimal T cell proliferation, cytokine production, and expression of the Bcl-2 family member Bcl-x(L), suggesting that ADAP regulates T cell activation by promoting antigen-dependent T cell-antigen presenting cell (APC) activation. At least three isoforms of ADAP are known to exist.
Especificaciones
Especificaciones
| Antígeno | ADAP |
| Aplicaciones | Western Blot, Immunocytochemistry |
| Clasificación | Polyclonal |
| Concentración | 1 mg/mL |
| Conjugado | Unconjugated |
| Formulación | PBS with 0.02% sodium azide |
| génica | FYB1 |
| N.º de referencia del gen | O15117 |
| Alias de gen | ADAP; adhesion and degranulation promoting adaptor protein; adhesion and degranulation-promoting adaptor protein; B630013F22Rik; Fyb; Fyb1; FYB-120/130; FYN binding protein; FYN binding protein (FYB-120/130); FYN binding protein FYB-130; FYN-binding protein; FYN-binding protein 1; FYN-T-binding protein; p120/130; p120/p130; PRO0823; RGD1563421; Slap130; SLAP-130; SLP-76-associated phosphoprotein |
| Símbolos de los genes | FYB1 |
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Título del producto
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