CAS RN 857290-04-1
IUPAC Nombre:
N-(6-aminopyridin-2-yl)-4'-cyano-[1,1'-biphenyl]-4-sulfonamide
Sinónimos:
N-(6-aminopyridin-2-yl)-4'-cyano-[1,1'-biphenyl]-4-sulfonamide
Peso molecular (g/mol):
350.4
Fórmula molecular:
C18H14N4O2S
InChi Key:
ZESFDAKNYJQYKO-UHFFFAOYSA-N
SMILES:
NC1=NC(NS(=O)(=O)C2=CC=C(C=C2)C2=CC=C(C=C2)C#N)=CC=C1
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Tocris Bioscience™ PF 915275
CAS: 857290-04-1 Fórmula molecular: C18H14N4O2S
2
PF-915275, MedChemExpress
MedChemExpress PF-915275 is a potent, selective and orally active human 11β-hydroxysteroid dehydrogenase type 1 (11βHSD1) inhibitor with a Ki of 2.3 nM and an EC50 of 15 nM (in HEK293 cells). The dose-dependent effect of PF-915275 on conversion of cortisone to cortisol in primary human and monkey hepatocytes, with an EC50 of 20 and 100 nM, respectively.
